Normocalcemic hyperparathyroidism and hypoparathyroidism in two community-based nonreferral populations

Natalie E. Cusano, Naim M. Maalouf, Patty Y. Wang, Chiyuan Zhang, Serge C. Cremers, Elizabeth Haney, Douglas C. Bauer, Eric Orwoll, John P. Bilezikian

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

Context: Normocalcemic primary hyperparathyroidism is typically identified after referral to a specialty clinic. At diagnosis, patients demonstrate features seen in hypercalcemic primary hyperparathyroidism. Normocalcemic hypoparathyroidism has been discovered after hypocalcemia unmasked after bisphosphonate administration. Objective: We hypothesized that screening unselected, nonreferral populations, such as The Osteoporotic Fractures in Men (MrOS) study and Dallas Heart Study (DHS), would identify asymptomatic subjects with normocalcemic hyperparathyroidism and hypoparathyroidism. Methods: Normocalcemic hyperparathyroidism was defined as serum PTH greater than the upper reference range with normal albumin-adjusted serum calcium, excluding common secondary causes (renal failure [estimated glomerular filtration rate

Original languageEnglish (US)
Pages (from-to)2734-2741
Number of pages8
JournalJournal of Clinical Endocrinology and Metabolism
Volume98
Issue number7
DOIs
StatePublished - Jul 2013

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Hypoparathyroidism
Primary Hyperparathyroidism
Hyperparathyroidism
Diphosphonates
Serum Albumin
Screening
Calcium
Osteoporotic Fractures
Hypocalcemia
Glomerular Filtration Rate
Population
Renal Insufficiency
Reference Values
Referral and Consultation
Serum

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Endocrinology
  • Biochemistry, medical
  • Endocrinology, Diabetes and Metabolism

Cite this

Normocalcemic hyperparathyroidism and hypoparathyroidism in two community-based nonreferral populations. / Cusano, Natalie E.; Maalouf, Naim M.; Wang, Patty Y.; Zhang, Chiyuan; Cremers, Serge C.; Haney, Elizabeth; Bauer, Douglas C.; Orwoll, Eric; Bilezikian, John P.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 98, No. 7, 07.2013, p. 2734-2741.

Research output: Contribution to journalArticle

Cusano, Natalie E. ; Maalouf, Naim M. ; Wang, Patty Y. ; Zhang, Chiyuan ; Cremers, Serge C. ; Haney, Elizabeth ; Bauer, Douglas C. ; Orwoll, Eric ; Bilezikian, John P. / Normocalcemic hyperparathyroidism and hypoparathyroidism in two community-based nonreferral populations. In: Journal of Clinical Endocrinology and Metabolism. 2013 ; Vol. 98, No. 7. pp. 2734-2741.
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