Normalization of 2-Week Postoperative Parathyroid Hormone Values in Patients with Primary Hyperparathyroidism: Four-gland exploration compared to focused-approach surgery

Peter J. Mazzaglia, Kresimira Milas, Eren Berber, Alan Siperstein, Jack M. Monchik

Research output: Contribution to journalArticle

6 Scopus citations


Background Elevation of parathyroid hormone (PTH) levels is commonly seen in patients with primary hyperparathyroidism (PHPT) who have undergone parathyroidectomy. This study evaluates differences in 2-week postoperative PTH levels in patients having focusedapproach surgery versus four-gland exploration. Methods Over 6 years, patients at Rhode Island Hospital (RIH) and the Cleveland Clinic (CCF) who had PHPT and underwent localization studies suggestive of single adenoma were analyzed. At RIH patients underwent focused-approach surgery, and at CCF routine four-gland exploration was performed. Postoperative calcium supplementation was routine at RIH and selective at CCF. Results There were 308 patients at RIH and 370 at CCF. They were similar in age (59.2±13.0 years at RIH and 60.4±12.9 years at CCF), and sex (76.9 and 80.0% female at RIH and CCF, respectively). The mean preoperative serum calcium measured 10.9±0.7 mg/dl at RIH and 11.1±0.7 mg/dl at CCF (P65 pg/ml in 18.8% at RIH and in 38.7% at CCF (P

Original languageEnglish (US)
Pages (from-to)1318-1324
Number of pages7
JournalWorld Journal of Surgery
Issue number6
Publication statusPublished - Jun 2010
Externally publishedYes


ASJC Scopus subject areas

  • Surgery

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