Normal fatty acid concentrations in young children with phenylketonuria

Stacey M. LaVoie, Cary Harding, Melanie Gillingham

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The objective of this study was to determine whether children with phenylketonuria (PKU) have lower fatty acid concentrations in total erythrocyte lipid due to the phenylalanine-restricted diet therapy compared to healthy control subjects. Dietary intake and fatty acid concentrations in total erythrocyte lipid were measured in 21 subjects (≤6 years of age) with PKU and 23 control children. Subjects with PKU had significantly lower protein and significantly higher polyunsaturated fat intake than controls. Subjects with PKU had significantly lower concentrations in total erythrocyte lipid of the sum of the ω-3, ω-6, saturated, and polyunsaturated fatty acids. Concentrations of fatty acids among subjects with PKU were lower than those among control subjects, but no subject with PKU exhibited any signs or symptoms suggestive of essential fatty acid deficiency, thereby suggesting that subjects with PKU in this cohort had normal and adequate essential fatty acid concentrations in total erythrocyte lipid.

Original languageEnglish (US)
Pages (from-to)333-340
Number of pages8
JournalTopics in Clinical Nutrition
Volume24
Issue number4
DOIs
StatePublished - Oct 2009

Fingerprint

Phenylketonurias
Fatty Acids
Erythrocytes
Lipids
Essential Fatty Acids
Diet Therapy
Phenylalanine
Unsaturated Fatty Acids
Signs and Symptoms
Healthy Volunteers
Fats

Keywords

  • Fatty acids
  • Lipids
  • Phenylketonuria
  • PKU

ASJC Scopus subject areas

  • Nutrition and Dietetics

Cite this

Normal fatty acid concentrations in young children with phenylketonuria. / LaVoie, Stacey M.; Harding, Cary; Gillingham, Melanie.

In: Topics in Clinical Nutrition, Vol. 24, No. 4, 10.2009, p. 333-340.

Research output: Contribution to journalArticle

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