Norepinephrine transporter mRNA is elevated in the locus coeruleus following short- and long-term desipramine treatment

Patricia Szot, Alexandra Ashliegh, Ruth Kohen, Eric Petrie, Daniel Dorsa, Richard Veith

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

In situ hybridization for the norepinephrine transporter (NET) mRNA was performed in animals receiving short-term (2 days) and long-term (4 weeks) treatment with desipramine (DMI; 10 mg/kg, intraperitoneal). Following short-term and long-term DMI treatment, a significant (P35S-labeled oligonucleotides to NET mRNA in the locus coeruleus was observed compared to that observed in vehicle-treated animals. The mechanism of this increase in transporter mRNA or its involvement in the therapeutic effects of anti-depressants remains to be determined.

Original languageEnglish (US)
Pages (from-to)308-312
Number of pages5
JournalBrain Research
Volume618
Issue number2
DOIs
StatePublished - Aug 6 1993
Externally publishedYes

Fingerprint

Norepinephrine Plasma Membrane Transport Proteins
Desipramine
Locus Coeruleus
Messenger RNA
Therapeutic Uses
Oligonucleotides
In Situ Hybridization

Keywords

  • Desipramine
  • Locus coeruleus
  • Norepinephrine transporter mRNA
  • Transporter
  • Tricyclic antidepressant

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Norepinephrine transporter mRNA is elevated in the locus coeruleus following short- and long-term desipramine treatment. / Szot, Patricia; Ashliegh, Alexandra; Kohen, Ruth; Petrie, Eric; Dorsa, Daniel; Veith, Richard.

In: Brain Research, Vol. 618, No. 2, 06.08.1993, p. 308-312.

Research output: Contribution to journalArticle

Szot, Patricia ; Ashliegh, Alexandra ; Kohen, Ruth ; Petrie, Eric ; Dorsa, Daniel ; Veith, Richard. / Norepinephrine transporter mRNA is elevated in the locus coeruleus following short- and long-term desipramine treatment. In: Brain Research. 1993 ; Vol. 618, No. 2. pp. 308-312.
@article{95d0709bcc6f42a584d22ba035b58b97,
title = "Norepinephrine transporter mRNA is elevated in the locus coeruleus following short- and long-term desipramine treatment",
abstract = "In situ hybridization for the norepinephrine transporter (NET) mRNA was performed in animals receiving short-term (2 days) and long-term (4 weeks) treatment with desipramine (DMI; 10 mg/kg, intraperitoneal). Following short-term and long-term DMI treatment, a significant (P35S-labeled oligonucleotides to NET mRNA in the locus coeruleus was observed compared to that observed in vehicle-treated animals. The mechanism of this increase in transporter mRNA or its involvement in the therapeutic effects of anti-depressants remains to be determined.",
keywords = "Desipramine, Locus coeruleus, Norepinephrine transporter mRNA, Transporter, Tricyclic antidepressant",
author = "Patricia Szot and Alexandra Ashliegh and Ruth Kohen and Eric Petrie and Daniel Dorsa and Richard Veith",
year = "1993",
month = "8",
day = "6",
doi = "10.1016/0006-8993(93)91281-V",
language = "English (US)",
volume = "618",
pages = "308--312",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier",
number = "2",

}

TY - JOUR

T1 - Norepinephrine transporter mRNA is elevated in the locus coeruleus following short- and long-term desipramine treatment

AU - Szot, Patricia

AU - Ashliegh, Alexandra

AU - Kohen, Ruth

AU - Petrie, Eric

AU - Dorsa, Daniel

AU - Veith, Richard

PY - 1993/8/6

Y1 - 1993/8/6

N2 - In situ hybridization for the norepinephrine transporter (NET) mRNA was performed in animals receiving short-term (2 days) and long-term (4 weeks) treatment with desipramine (DMI; 10 mg/kg, intraperitoneal). Following short-term and long-term DMI treatment, a significant (P35S-labeled oligonucleotides to NET mRNA in the locus coeruleus was observed compared to that observed in vehicle-treated animals. The mechanism of this increase in transporter mRNA or its involvement in the therapeutic effects of anti-depressants remains to be determined.

AB - In situ hybridization for the norepinephrine transporter (NET) mRNA was performed in animals receiving short-term (2 days) and long-term (4 weeks) treatment with desipramine (DMI; 10 mg/kg, intraperitoneal). Following short-term and long-term DMI treatment, a significant (P35S-labeled oligonucleotides to NET mRNA in the locus coeruleus was observed compared to that observed in vehicle-treated animals. The mechanism of this increase in transporter mRNA or its involvement in the therapeutic effects of anti-depressants remains to be determined.

KW - Desipramine

KW - Locus coeruleus

KW - Norepinephrine transporter mRNA

KW - Transporter

KW - Tricyclic antidepressant

UR - http://www.scopus.com/inward/record.url?scp=0027201510&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027201510&partnerID=8YFLogxK

U2 - 10.1016/0006-8993(93)91281-V

DO - 10.1016/0006-8993(93)91281-V

M3 - Article

C2 - 8374761

AN - SCOPUS:0027201510

VL - 618

SP - 308

EP - 312

JO - Brain Research

JF - Brain Research

SN - 0006-8993

IS - 2

ER -