Norepinephrine transporter mRNA is elevated in the locus coeruleus following short- and long-term desipramine treatment

Patricia Szot, Alexandra Ashliegh, Ruth Kohen, Eric Petrie, Daniel M. Dorsa, Richard Veith

Research output: Contribution to journalArticle

56 Scopus citations

Abstract

In situ hybridization for the norepinephrine transporter (NET) mRNA was performed in animals receiving short-term (2 days) and long-term (4 weeks) treatment with desipramine (DMI; 10 mg/kg, intraperitoneal). Following short-term and long-term DMI treatment, a significant (P<0.05) increase in hybridizatino of 35S-labeled oligonucleotides to NET mRNA in the locus coeruleus was observed compared to that observed in vehicle-treated animals. The mechanism of this increase in transporter mRNA or its involvement in the therapeutic effects of anti-depressants remains to be determined.

Original languageEnglish (US)
Pages (from-to)308-312
Number of pages5
JournalBrain research
Volume618
Issue number2
DOIs
StatePublished - Aug 6 1993

Keywords

  • Desipramine
  • Locus coeruleus
  • Norepinephrine transporter mRNA
  • Transporter
  • Tricyclic antidepressant

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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