Norepinephrine regulation of fetal heart rate

Multiple mechanisms of action

Cecilia Cheung, Robert A. Brace

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Norepinephrine was infused intravenously for 30 minutes into chronically catheterized sheep fetuses averaging 133 days' gestation. At infusion rates of 3.9, 12, and 39 μg/min, heart rate initially decreased as much as 40 bpm and then gradually increased to 50 bpm above the control value by the end of the infusion. Thereafer, heart rate increased further, and by the end of a 30-minute recovery period, heart rate was still 66 bpm above the control value. In fetuses pretreated with either a ganglionic blocker or a parasympathetic blocker, norepinephrine caused a large and sustained rise in heart rate by 124 bpm, which declined rapidly when the infusion was terminated. These results suggest that circulating norepinephrine affects fetal heart by several mechanisms: (1) a baroreceptor-mediated suppression, (2) a direct stimulation by norepinephrine, (3) a gradual weakening of the vagal suppression, and (4) an increase in cardiac sensitivity to sympathetic stimulation. In addition, there appears to be a long-term positive correlation between fetal heart rate and circulating norepinephrine levels.

Original languageEnglish (US)
Pages (from-to)1254-1259
Number of pages6
JournalAmerican Journal of Obstetrics and Gynecology
Volume156
Issue number5
DOIs
StatePublished - 1987
Externally publishedYes

Fingerprint

Fetal Heart Rate
Norepinephrine
Heart Rate
Fetus
Ganglionic Blockers
Fetal Heart
Pressoreceptors
Sheep
Pregnancy

Keywords

  • autonomic nervous system
  • Fetus
  • heart rate
  • norepinephrine

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

Cite this

Norepinephrine regulation of fetal heart rate : Multiple mechanisms of action. / Cheung, Cecilia; Brace, Robert A.

In: American Journal of Obstetrics and Gynecology, Vol. 156, No. 5, 1987, p. 1254-1259.

Research output: Contribution to journalArticle

Cheung, Cecilia ; Brace, Robert A. / Norepinephrine regulation of fetal heart rate : Multiple mechanisms of action. In: American Journal of Obstetrics and Gynecology. 1987 ; Vol. 156, No. 5. pp. 1254-1259.
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