Norepinephrine increases cyclic GMP levels in cerebellar cells from neuronal nitric oxide synthase knockout mice

David B. Morton, David S. Bredt

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Cyclic GMP is an important intracellular messenger in the nervous system that may mediate cellular forms of neuronal plasticity. Previous studies show that most neurotransmitters stimulate cyclic GMP levels by the activation of nitric oxide synthase (NOS). In this study, we report that in primary cell cultures from the cerebellum of neuronal NOS knockout mice, norepinephrine stimulates an increase in cyclic GMP content. This increase is seen in both granule cell and astrocyte cultures and is not blocked by inhibitors of NOS or by inhibition of soluble guanylyl cyclase. These results suggest a novel pathway by which norepinephrine enhances cyclic GMP levels in the nervous system.

Original languageEnglish (US)
Pages (from-to)440-443
Number of pages4
JournalJournal of Neurochemistry
Volume71
Issue number1
StatePublished - Jul 1 1998

Keywords

  • Cellular plasticity
  • Guanylyl cyclase

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

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