Noradrenergic mechanisms in fentanyl-mediated rapid death explain failure of naloxone in the opioid crisis

Medicine & Life Sciences

• Opioid Epidemic 100%
• Fentanyl 74%
• Naloxone 73%
• Respiratory Insufficiency 9%
• Morphine 9%
• Thorax 9%
• Alkaloids 7%
• Anesthesiologists 7%
• Cholinergic Agents 6%
• Opioid Analgesics 6%
• Addiction Medicine 5%
• Muscle Rigidity 4%
• Abdominal Muscles 4%
• Anesthesiology 4%
• Clinical Pharmacology 4%
• Airway Management 4%
• Heroin 3%
• Prodrugs 3%
• Thoracic Wall 3%
• Centers for Disease Control and Prevention (U.S.) 3%
• Diaphragm 3%
• Cardiovascular System 3%
• Adrenergic Agents 3%
• Drug Development 3%
• Respiratory System 3%
• Analgesia 3%
• Pharmaceutical Preparations 2%
• Cause of Death 2%
• Anesthesia 2%
• Hemodynamics 2%
• Research Personnel 2%
• Animals 1%
• Population 1%
• Therapeutics 0%