Nonvisual photoreception in the chick iris

Daniel Tu, Matthew L. Batten, Krzysztof Palczewski, Russell N. Van Gelder

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

The embryonic chicken iris constricts to light ex vivo, but with characteristics atypical of visual phototransduction. The chick iris was most sensitive to short-wavelength light, demonstrating an action spectrum consistent with cryptochrome rather than with opsin pigments. Pupillary responses did not attenuate after saturating light exposure, but showed paradoxical potentiation. Iris photosensitivity was not affected by retinoid depletion or inhibitors of visual phototransduction. Knockdown of cryptochrome expression, but not of melanopsin expression, decreased iris photosensitivity. These data characterize a non-opsin photoreception mechanism in a vertebrate eye and suggest a conserved photoreceptive role for cryptochromes in vertebrates.

Original languageEnglish (US)
Pages (from-to)129-131
Number of pages3
JournalScience
Volume306
Issue number5693
DOIs
StatePublished - Oct 1 2004
Externally publishedYes

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Cryptochromes
Iris
Light
Vertebrates
Opsins
Retinoids
Chickens

ASJC Scopus subject areas

  • General

Cite this

Tu, D., Batten, M. L., Palczewski, K., & Van Gelder, R. N. (2004). Nonvisual photoreception in the chick iris. Science, 306(5693), 129-131. https://doi.org/10.1126/science.1101484

Nonvisual photoreception in the chick iris. / Tu, Daniel; Batten, Matthew L.; Palczewski, Krzysztof; Van Gelder, Russell N.

In: Science, Vol. 306, No. 5693, 01.10.2004, p. 129-131.

Research output: Contribution to journalArticle

Tu, D, Batten, ML, Palczewski, K & Van Gelder, RN 2004, 'Nonvisual photoreception in the chick iris', Science, vol. 306, no. 5693, pp. 129-131. https://doi.org/10.1126/science.1101484
Tu D, Batten ML, Palczewski K, Van Gelder RN. Nonvisual photoreception in the chick iris. Science. 2004 Oct 1;306(5693):129-131. https://doi.org/10.1126/science.1101484
Tu, Daniel ; Batten, Matthew L. ; Palczewski, Krzysztof ; Van Gelder, Russell N. / Nonvisual photoreception in the chick iris. In: Science. 2004 ; Vol. 306, No. 5693. pp. 129-131.
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