Nonuniform probability of glutamate release at a hippocampal synapse

Christian Rosenmund, John D. Clements, Gary Westbrook

Research output: Contribution to journalArticle

473 Citations (Scopus)

Abstract

A change in the probability of neurotransmitter release (Pr) is an important mechanism underlying synaptic plasticity. Although Pr is often assumed to be the same for all terminals at a single synapse, this assumption is difficult to reconcile with the nonuniform size and structure of synaptic terminals in the central nervous system. Release probability was measured at excitatory synapses on cultured hippocampal neurons by analysis of the progressive block of N-methyl-D-aspartate receptor-mediated synaptic currents by the irreversible open channel blocker MK-801. Release probability was nonuniform (range of 0.09 to 0.54) for terminals arising from a single axon, the majority of which had a low Pr. However, terminals with high Pr are more likely to be affected by the activity-dependent modulation that occurs in long-term potentiation.

Original languageEnglish (US)
Pages (from-to)754-757
Number of pages4
JournalScience
Volume262
Issue number5134
StatePublished - 1993

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Synapses
Glutamic Acid
Neuronal Plasticity
Dizocilpine Maleate
Long-Term Potentiation
Presynaptic Terminals
N-Methyl-D-Aspartate Receptors
Neurotransmitter Agents
Axons
Central Nervous System
Neurons

ASJC Scopus subject areas

  • General

Cite this

Rosenmund, C., Clements, J. D., & Westbrook, G. (1993). Nonuniform probability of glutamate release at a hippocampal synapse. Science, 262(5134), 754-757.

Nonuniform probability of glutamate release at a hippocampal synapse. / Rosenmund, Christian; Clements, John D.; Westbrook, Gary.

In: Science, Vol. 262, No. 5134, 1993, p. 754-757.

Research output: Contribution to journalArticle

Rosenmund, C, Clements, JD & Westbrook, G 1993, 'Nonuniform probability of glutamate release at a hippocampal synapse', Science, vol. 262, no. 5134, pp. 754-757.
Rosenmund, Christian ; Clements, John D. ; Westbrook, Gary. / Nonuniform probability of glutamate release at a hippocampal synapse. In: Science. 1993 ; Vol. 262, No. 5134. pp. 754-757.
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