Nonmyelin-specific T cells accelerate development of central nervous system APC and increase susceptibility to experimental autoimmune encephalomyelitis

Richard E. Jones, Thomas Kay, Thomas Keller, Dennis Bourdette

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Previously we demonstrated that both myelin-specific and nonmyelin-specific rat T cells were capable of accelerating the development of transplanted rat BM-derived APC in the CNS of SCID C.B-17/scid (SCID) mice. This suggested that nonmyelin-specific T cells might be capable of increasing susceptibility to EAE by increasing the number and function of APC in the CNS before disease induction. To assess this possibility, we evaluated disease incidence, day of onset, duration, mean peak severity, cumulative disease index, and histopathology in the presence or absence of nonmyelin-specific T cells. The results demonstrate an association between T cell responses to nonmyelin Ags, accelerated development of BM-derived CNS APC before disease induction, and heightened susceptibility to CNS inflammation mediated by myelin-specific T cells. This suggests that T cell responses to nonmyelin Ags can potentiate CNS inflammation by elevating the functional presence of CNS APC.

Original languageEnglish (US)
Pages (from-to)831-837
Number of pages7
JournalJournal of Immunology
Volume170
Issue number2
StatePublished - Jan 15 2003
Externally publishedYes

Fingerprint

Autoimmune Experimental Encephalomyelitis
Central Nervous System
T-Lymphocytes
Myelin Sheath
Inflammation
SCID Mice
Central Nervous System Diseases
Incidence

ASJC Scopus subject areas

  • Immunology

Cite this

Nonmyelin-specific T cells accelerate development of central nervous system APC and increase susceptibility to experimental autoimmune encephalomyelitis. / Jones, Richard E.; Kay, Thomas; Keller, Thomas; Bourdette, Dennis.

In: Journal of Immunology, Vol. 170, No. 2, 15.01.2003, p. 831-837.

Research output: Contribution to journalArticle

@article{75256b1446a84db2a82c68a591c37ada,
title = "Nonmyelin-specific T cells accelerate development of central nervous system APC and increase susceptibility to experimental autoimmune encephalomyelitis",
abstract = "Previously we demonstrated that both myelin-specific and nonmyelin-specific rat T cells were capable of accelerating the development of transplanted rat BM-derived APC in the CNS of SCID C.B-17/scid (SCID) mice. This suggested that nonmyelin-specific T cells might be capable of increasing susceptibility to EAE by increasing the number and function of APC in the CNS before disease induction. To assess this possibility, we evaluated disease incidence, day of onset, duration, mean peak severity, cumulative disease index, and histopathology in the presence or absence of nonmyelin-specific T cells. The results demonstrate an association between T cell responses to nonmyelin Ags, accelerated development of BM-derived CNS APC before disease induction, and heightened susceptibility to CNS inflammation mediated by myelin-specific T cells. This suggests that T cell responses to nonmyelin Ags can potentiate CNS inflammation by elevating the functional presence of CNS APC.",
author = "Jones, {Richard E.} and Thomas Kay and Thomas Keller and Dennis Bourdette",
year = "2003",
month = "1",
day = "15",
language = "English (US)",
volume = "170",
pages = "831--837",
journal = "Journal of Immunology",
issn = "0022-1767",
publisher = "American Association of Immunologists",
number = "2",

}

TY - JOUR

T1 - Nonmyelin-specific T cells accelerate development of central nervous system APC and increase susceptibility to experimental autoimmune encephalomyelitis

AU - Jones, Richard E.

AU - Kay, Thomas

AU - Keller, Thomas

AU - Bourdette, Dennis

PY - 2003/1/15

Y1 - 2003/1/15

N2 - Previously we demonstrated that both myelin-specific and nonmyelin-specific rat T cells were capable of accelerating the development of transplanted rat BM-derived APC in the CNS of SCID C.B-17/scid (SCID) mice. This suggested that nonmyelin-specific T cells might be capable of increasing susceptibility to EAE by increasing the number and function of APC in the CNS before disease induction. To assess this possibility, we evaluated disease incidence, day of onset, duration, mean peak severity, cumulative disease index, and histopathology in the presence or absence of nonmyelin-specific T cells. The results demonstrate an association between T cell responses to nonmyelin Ags, accelerated development of BM-derived CNS APC before disease induction, and heightened susceptibility to CNS inflammation mediated by myelin-specific T cells. This suggests that T cell responses to nonmyelin Ags can potentiate CNS inflammation by elevating the functional presence of CNS APC.

AB - Previously we demonstrated that both myelin-specific and nonmyelin-specific rat T cells were capable of accelerating the development of transplanted rat BM-derived APC in the CNS of SCID C.B-17/scid (SCID) mice. This suggested that nonmyelin-specific T cells might be capable of increasing susceptibility to EAE by increasing the number and function of APC in the CNS before disease induction. To assess this possibility, we evaluated disease incidence, day of onset, duration, mean peak severity, cumulative disease index, and histopathology in the presence or absence of nonmyelin-specific T cells. The results demonstrate an association between T cell responses to nonmyelin Ags, accelerated development of BM-derived CNS APC before disease induction, and heightened susceptibility to CNS inflammation mediated by myelin-specific T cells. This suggests that T cell responses to nonmyelin Ags can potentiate CNS inflammation by elevating the functional presence of CNS APC.

UR - http://www.scopus.com/inward/record.url?scp=0037438487&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037438487&partnerID=8YFLogxK

M3 - Article

C2 - 12517947

AN - SCOPUS:0037438487

VL - 170

SP - 831

EP - 837

JO - Journal of Immunology

JF - Journal of Immunology

SN - 0022-1767

IS - 2

ER -