Noninvasive quantification of coronary blood flow reserve in humans using myocardial contrast echocardiography

Kevin Wei, Michael Ragosta, Jerrel Thorpe, Matthew Coggins, Sally Moos, Sanjiv Kaul

Research output: Contribution to journalArticle

204 Scopus citations


Background - We hypothesized that coronary blood flow (CBF) reserve could be quantified noninvasively in humans using myocardial contrast echocardiography (MCE). Methods and Results - Eleven patients with normal epicardial coronary arteries (group I) and 19 with single-vessel coronary stenosis (group II) underwent quantitative coronary angiography, MCE, and CBF velocity measurements at rest and during intravenous adenosine infusion. In group I patients, MCE-derived myocardial blood flow (MBF) velocity reserve (2.4±0.08) was similar to CBF velocity reserve using a Doppler flow wire (2.4±1.1). Patients with a single risk factor had a significantly higher MBF reserve (3.0±0.89) than those with ≥2 risk factors (1.7±0.22). In group II patients, significant differences were found in MBF velocity reserve in patients with mild 75%) stenoses (2.2±0.40, 1.6±0.65, and 0.55±0.19, respectively; P=0.005). A linear relation was found between flow velocity reserve determined using the 2 methods (r=0.76, P

Original languageEnglish (US)
Pages (from-to)2560-2565
Number of pages6
Issue number21
Publication statusPublished - May 29 2001
Externally publishedYes



  • Blood flow
  • Contrast media
  • Coronary disease
  • Echocardiography

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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