Noninvasive prediction of ultimate infarct size at the time of acute coronary occlusion based on the extent and magnitude of collateral-derived myocardial blood flow

Matthew P. Coggins, Jiri Sklenar, Dai-Trang (Elizabeth) Le, Kevin Wei, Jonathan Lindner, Sanjiv Kaul

Research output: Contribution to journalArticle

104 Citations (Scopus)

Abstract

Background - We hypothesized that by detecting regions with adequate collateral-derived myocardial blood flow (MBF) within the risk area (RA), we could predict ultimate infarct size (IS) at the time of coronary occlusion. Methods and Results - Group 1 dogs (n=15) underwent coronary occlusion without reperfusion, whereas group 2 dogs (n=6) underwent both occlusion and reperfusion. RA was measured with aortic root injections of microbubbles. Myocardial contrast echocardiography (MCE) was performed with high mechanical index intermittent harmonic imaging at pulsing intervals (PIs) of

Original languageEnglish (US)
Pages (from-to)2471-2477
Number of pages7
JournalCirculation
Volume104
Issue number20
StatePublished - Nov 13 2001
Externally publishedYes

Fingerprint

Coronary Occlusion
Reperfusion
Dogs
Microbubbles
Echocardiography
Injections

Keywords

  • Collateral circulation
  • Contrast media
  • Infarction

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

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abstract = "Background - We hypothesized that by detecting regions with adequate collateral-derived myocardial blood flow (MBF) within the risk area (RA), we could predict ultimate infarct size (IS) at the time of coronary occlusion. Methods and Results - Group 1 dogs (n=15) underwent coronary occlusion without reperfusion, whereas group 2 dogs (n=6) underwent both occlusion and reperfusion. RA was measured with aortic root injections of microbubbles. Myocardial contrast echocardiography (MCE) was performed with high mechanical index intermittent harmonic imaging at pulsing intervals (PIs) of",
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T1 - Noninvasive prediction of ultimate infarct size at the time of acute coronary occlusion based on the extent and magnitude of collateral-derived myocardial blood flow

AU - Coggins, Matthew P.

AU - Sklenar, Jiri

AU - Le, Dai-Trang (Elizabeth)

AU - Wei, Kevin

AU - Lindner, Jonathan

AU - Kaul, Sanjiv

PY - 2001/11/13

Y1 - 2001/11/13

N2 - Background - We hypothesized that by detecting regions with adequate collateral-derived myocardial blood flow (MBF) within the risk area (RA), we could predict ultimate infarct size (IS) at the time of coronary occlusion. Methods and Results - Group 1 dogs (n=15) underwent coronary occlusion without reperfusion, whereas group 2 dogs (n=6) underwent both occlusion and reperfusion. RA was measured with aortic root injections of microbubbles. Myocardial contrast echocardiography (MCE) was performed with high mechanical index intermittent harmonic imaging at pulsing intervals (PIs) of

AB - Background - We hypothesized that by detecting regions with adequate collateral-derived myocardial blood flow (MBF) within the risk area (RA), we could predict ultimate infarct size (IS) at the time of coronary occlusion. Methods and Results - Group 1 dogs (n=15) underwent coronary occlusion without reperfusion, whereas group 2 dogs (n=6) underwent both occlusion and reperfusion. RA was measured with aortic root injections of microbubbles. Myocardial contrast echocardiography (MCE) was performed with high mechanical index intermittent harmonic imaging at pulsing intervals (PIs) of

KW - Collateral circulation

KW - Contrast media

KW - Infarction

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