Diabetic retinopathy, age-related macular degeneration, and glaucoma are all associated with impaired circulation. Noninvasive assessment of ocular circulation would be very powerful for understanding and diagnosing these eye diseases. Using high-speed optical coherence tomography (OCT), we developed a new OCT angiography algorithm called split-spectrum amplitude-decorrelation angiography (SSADA) for imaging ocular microcirculation. Here, the system and theory of this novel OCT angiography technique are reviewed; its capabilities for imaging retinal, choroidal, and optic nerve head blood flow are demonstrated; and its limitation is discussed.
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