Noninvasive blood tests for fetal development predict gestational age and preterm delivery

Thuy Ngo, Mira N. Moufarrej, Marie Louise H. Rasmussen, Joan Camunas-Soler, Wenying Pan, Jennifer Okamoto, Norma F. Neff, Keli Liu, Ronald J. Wong, Katheryne Downes, Robert Tibshirani, Gary M. Shaw, Line Skotte, David K. Stevenson, Joseph R. Biggio, Michal A. Elovitz, Mads Melbye, Stephen R. Quake

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Noninvasive blood tests that provide information about fetal development and gestational age could potentially improve prenatal care. Ultrasound, the current gold standard, is not always affordable in low-resource settings and does not predict spontaneous preterm birth, a leading cause of infant death. In a pilot study of 31 healthy pregnant women, we found that measurement of nine cell-free RNA (cfRNA) transcripts in maternal blood predicted gestational age with comparable accuracy to ultrasound but at substantially lower cost. In a related study of 38 women (25 full-term and 13 preterm deliveries), all at elevated risk of delivering preterm, we identified seven cfRNA transcripts that accurately classified women who delivered preterm up to 2 months in advance of labor. These tests hold promise for prenatal care in both the developed and developing worlds, although they require validation in larger, blinded clinical trials.

Original languageEnglish (US)
Pages (from-to)1133-1136
Number of pages4
JournalScience
Volume360
Issue number6393
DOIs
StatePublished - Jun 8 2018

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Hematologic Tests
Fetal Development
Gestational Age
Prenatal Care
RNA
Premature Birth
Pregnant Women
Cause of Death
Mothers
Clinical Trials
Costs and Cost Analysis

ASJC Scopus subject areas

  • General

Cite this

Ngo, T., Moufarrej, M. N., Rasmussen, M. L. H., Camunas-Soler, J., Pan, W., Okamoto, J., ... Quake, S. R. (2018). Noninvasive blood tests for fetal development predict gestational age and preterm delivery. Science, 360(6393), 1133-1136. https://doi.org/10.1126/science.aar3819

Noninvasive blood tests for fetal development predict gestational age and preterm delivery. / Ngo, Thuy; Moufarrej, Mira N.; Rasmussen, Marie Louise H.; Camunas-Soler, Joan; Pan, Wenying; Okamoto, Jennifer; Neff, Norma F.; Liu, Keli; Wong, Ronald J.; Downes, Katheryne; Tibshirani, Robert; Shaw, Gary M.; Skotte, Line; Stevenson, David K.; Biggio, Joseph R.; Elovitz, Michal A.; Melbye, Mads; Quake, Stephen R.

In: Science, Vol. 360, No. 6393, 08.06.2018, p. 1133-1136.

Research output: Contribution to journalArticle

Ngo, T, Moufarrej, MN, Rasmussen, MLH, Camunas-Soler, J, Pan, W, Okamoto, J, Neff, NF, Liu, K, Wong, RJ, Downes, K, Tibshirani, R, Shaw, GM, Skotte, L, Stevenson, DK, Biggio, JR, Elovitz, MA, Melbye, M & Quake, SR 2018, 'Noninvasive blood tests for fetal development predict gestational age and preterm delivery', Science, vol. 360, no. 6393, pp. 1133-1136. https://doi.org/10.1126/science.aar3819
Ngo T, Moufarrej MN, Rasmussen MLH, Camunas-Soler J, Pan W, Okamoto J et al. Noninvasive blood tests for fetal development predict gestational age and preterm delivery. Science. 2018 Jun 8;360(6393):1133-1136. https://doi.org/10.1126/science.aar3819
Ngo, Thuy ; Moufarrej, Mira N. ; Rasmussen, Marie Louise H. ; Camunas-Soler, Joan ; Pan, Wenying ; Okamoto, Jennifer ; Neff, Norma F. ; Liu, Keli ; Wong, Ronald J. ; Downes, Katheryne ; Tibshirani, Robert ; Shaw, Gary M. ; Skotte, Line ; Stevenson, David K. ; Biggio, Joseph R. ; Elovitz, Michal A. ; Melbye, Mads ; Quake, Stephen R. / Noninvasive blood tests for fetal development predict gestational age and preterm delivery. In: Science. 2018 ; Vol. 360, No. 6393. pp. 1133-1136.
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