Nonhuman primate models of human immunology

Ilhem Messaoudi, Ryan Estep, Bridget Robinson, Scott W. Wong

Research output: Contribution to journalReview article

63 Scopus citations

Abstract

Nonhuman primates have been used for biomedical research for several decades. The high level of genetic homology to humans coupled with their outbred nature has made nonhuman primates invaluable preclinical models. In this review, we summarize recent advances in our understanding of the nonhuman primate immune system, with special emphasis on studies carried out in rhesus macaque (Macaca mulatta). We highlight the utility of nonhuman primates in the characterization of immune senescence and the evaluation of new interventions to slow down the aging of the immune system.

Original languageEnglish (US)
Pages (from-to)261-273
Number of pages13
JournalAntioxidants and Redox Signaling
Volume14
Issue number2
DOIs
StatePublished - Jan 15 2011

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ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology

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