Nonalcoholic Fatty Liver Disease and Cardiovascular Risk: A Scientific Statement From the American Heart Association

American Heart Association Council on Arteriosclerosis, Thrombosis and Vascular Biology; Council on Hypertension; Council on the Kidney in Cardiovascular Disease; Council on Lifestyle and Cardiometabolic Health; and Council on Peripheral Vascular Disease

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations

Abstract

Nonalcoholic fatty liver disease (NAFLD) is an increasingly common condition that is believed to affect >25% of adults worldwide. Unless specific testing is done to identify NAFLD, the condition is typically silent until advanced and potentially irreversible liver impairment occurs. For this reason, the majority of patients with NAFLD are unaware of having this serious condition. Hepatic complications from NAFLD include nonalcoholic steatohepatitis, hepatic cirrhosis, and hepatocellular carcinoma. In addition to these serious complications, NAFLD is a risk factor for atherosclerotic cardiovascular disease, which is the principal cause of death in patients with NAFLD. Accordingly, the purpose of this scientific statement is to review the underlying risk factors and pathophysiology of NAFLD, the associations with atherosclerotic cardiovascular disease, diagnostic and screening strategies, and potential interventions.

Original languageEnglish (US)
Pages (from-to)e168-e185
JournalArteriosclerosis, thrombosis, and vascular biology
Volume42
Issue number6
DOIs
StatePublished - Jun 1 2022

Keywords

  • AHA Scientific Statements
  • cardiovascular diseases
  • diabetes mellitus
  • hepatocytes
  • hypertriglyceridemia
  • insulin resistance
  • metabolic syndrome
  • nonalcoholic fatty liver disease
  • triglycerides

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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