TY - JOUR
T1 - Non-specific orbital inflammation
T2 - Current understanding and unmet needs
AU - Lee, Min Joung
AU - Planck, Stephen R.
AU - Choi, Dongseok
AU - Harrington, Christina A.
AU - Wilson, David J.
AU - Dailey, Roger A.
AU - Ng, John D.
AU - Steele, Eric A.
AU - Hamilton, Bronwyn E.
AU - Khwarg, Sang In
AU - Rosenbaum, James T.
N1 - Funding Information:
The authors are grateful for funding support from the National Eye Institute (Grants EY020249 and P30 EY 010572 ), and funding from the Grandmaison Fund for Autoimmunity Research , the Stan and Madelle Rosenfeld Family Trust , the William and Mary Bauman Foundation , and Research to Prevent Blindness , New York.
Funding Information:
The authors are grateful for funding support from the National Eye Institute (Grants EY020249 and P30 EY 010572), and funding from the Grandmaison Fund for Autoimmunity Research, the Stan and Madelle Rosenfeld Family Trust, the William and Mary Bauman Foundation, and Research to Prevent Blindness, New York. This work would not be possible without the efforts of the Orbital Inflammatory Disease Consortium which includes David J Wilson, Hans Grossniklaus, Roger Dailey, John Ng, Eric Steele, Craig Czyz, Jill Foster, David Tse, Chris Alabiad, Sander Dubovy, Prashant Parekh, Gerald Harris, Michael Kazim, Payal Patel, Valerie White, Peter Dolman, Bobby Korn, Don Kikkawa, Deepak Edward, Hind Alkatan, Hailah Al-Hussain, R. Patrick Yeatts, Dinesh Selva, Rohan Verma, Hadi Khazaei, and Rona Sikliss. The authors thank Garcia Armando, Thomas Clark, and Lance Bodily for their help to collect clinical data.
Funding Information:
Dr. Rosenbaum is a consultant to Janssen, Abbvie, Roche, UpToDate, Novartis, Gilead, UCB, Santen, Horizon, Corvus, Celldex, Lilly, and Eyevensys, and has received research funding from Alcon Research Institute and Pfizer. Dr. Dailey is a consultant to Horizon and Bio-logic Aqua Research Inc. and Dr. Ng is a consultants to Bio-logic Aqua Research Inc. The other authors report no conflicts of interest.
Publisher Copyright:
© 2020
PY - 2021/3
Y1 - 2021/3
N2 - Non-specific orbital inflammation (NSOI) is a noninfectious inflammatory condition of the orbit. Although it is generally considered the most common diagnosis derived from an orbital biopsy, it is a diagnosis of exclusion, meaning that the diagnosis requires exclusion of a systemic process or another identifiable etiology of orbital inflammation. The clinical diagnosis of NSOI is ill-defined, but it is typically characterized by acute orbital signs and symptoms, including pain, proptosis, periorbital edema, chemosis, diplopia, and less commonly visual disturbance. NSOI poses a diagnostic and therapeutic challenge: The clinical presentations and histological findings are heterogeneous, and there are no specific diagnostic criteria or treatment guidelines. The etiology and pathogenesis of NSOI are poorly understood. Here we recapitulate our current clinical understanding of NSOI, with an emphasis on the most recent findings on clinical characteristics, imaging findings, and treatment outcomes. Furthermore, gene expression profiling of NSOI and its implications are presented and discussed.
AB - Non-specific orbital inflammation (NSOI) is a noninfectious inflammatory condition of the orbit. Although it is generally considered the most common diagnosis derived from an orbital biopsy, it is a diagnosis of exclusion, meaning that the diagnosis requires exclusion of a systemic process or another identifiable etiology of orbital inflammation. The clinical diagnosis of NSOI is ill-defined, but it is typically characterized by acute orbital signs and symptoms, including pain, proptosis, periorbital edema, chemosis, diplopia, and less commonly visual disturbance. NSOI poses a diagnostic and therapeutic challenge: The clinical presentations and histological findings are heterogeneous, and there are no specific diagnostic criteria or treatment guidelines. The etiology and pathogenesis of NSOI are poorly understood. Here we recapitulate our current clinical understanding of NSOI, with an emphasis on the most recent findings on clinical characteristics, imaging findings, and treatment outcomes. Furthermore, gene expression profiling of NSOI and its implications are presented and discussed.
KW - Gene-expression profiling
KW - Granulomatosis with polyangiitis
KW - IgG4-related ophthalmic diseases
KW - Nonspecific orbital inflammation
KW - Orbital sarcoidosis
KW - Thyroid eye disease
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U2 - 10.1016/j.preteyeres.2020.100885
DO - 10.1016/j.preteyeres.2020.100885
M3 - Review article
C2 - 32717379
AN - SCOPUS:85089158450
VL - 81
JO - Progress in Retinal and Eye Research
JF - Progress in Retinal and Eye Research
SN - 1350-9462
M1 - 100885
ER -