Non-replication of an association of Apolipoprotein E2 with sinistrality

Brian J. Piper, Alia L. Yasen, Amy E. Taylor, Jonatan R. Ruiz, J. William Gaynor, Catherine A. Dayger, Marcela Gonzalez-Gross, Oh D. Kwon, Lars Göran Nilsson, Ian N.M. Day, Jacob Raber, Jeremy K. Miller

Research output: Contribution to journalArticle

13 Scopus citations


A recent report found that left-handed adolescents were more than three times more likely to have an Apolipoprotein (APOE) ε2 allele. This study was unable to replicate this association in young adults (N=166). A meta-analysis of nine other datasets (N=360 to 7559, Power > 0.999) including that of National Alzheimer's Coordinating Center also failed to find an over-representation of ε2 among left-handers indicating that this earlier outcome was most likely a statistical artefact.

Original languageEnglish (US)
Pages (from-to)251-261
Number of pages11
Issue number2
StatePublished - Mar 2013


  • APOE
  • Handedness
  • Right

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Psychology(all)

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    Piper, B. J., Yasen, A. L., Taylor, A. E., Ruiz, J. R., Gaynor, J. W., Dayger, C. A., Gonzalez-Gross, M., Kwon, O. D., Nilsson, L. G., Day, I. N. M., Raber, J., & Miller, J. K. (2013). Non-replication of an association of Apolipoprotein E2 with sinistrality. Laterality, 18(2), 251-261.