Abstract
Vulnerable plaque is characterized by a large necrotic core and an overlying thin fibrous cap. Non-invasive imaging modalities such as computed tomography angiography (CTA) and magnetic resonance imaging (MRI) allow for the assessment of morphological plaque characteristics, while positron emission tomography (PET) enables the detection of metabolic activity within the atherosclerotic lesions. Invasive imaging modalities such as intravascular ultrasound (IVUS), optical-coherence tomography (OCT), and intravascular MRI (IV-MRI) display plaques at a high spatial resolution. Near-infrared spectroscopy (NIRS) allows for the detection of chemical components of atherosclerotic plaques. In this review, we describe state-of-the-art non-invasive and invasive imaging modalities and stress the combination of their advantages to identify vulnerable plaque features.
| Original language | English (US) |
|---|---|
| Journal | Trends in Cardiovascular Medicine |
| DOIs | |
| State | Accepted/In press - 2016 |
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Keywords
- Coronary artery disease
- Necrotic core
- Thin-cap fibroatheroma
- Vulnerable plaque
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Non-invasive and invasive imaging of vulnerable coronary plaque. / Celeng, Csilla; Takx, Richard A P; Ferencik, Maros; Maurovich-Horvat, Pál.
In: Trends in Cardiovascular Medicine, 2016.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Non-invasive and invasive imaging of vulnerable coronary plaque
AU - Celeng, Csilla
AU - Takx, Richard A P
AU - Ferencik, Maros
AU - Maurovich-Horvat, Pál
PY - 2016
Y1 - 2016
N2 - Vulnerable plaque is characterized by a large necrotic core and an overlying thin fibrous cap. Non-invasive imaging modalities such as computed tomography angiography (CTA) and magnetic resonance imaging (MRI) allow for the assessment of morphological plaque characteristics, while positron emission tomography (PET) enables the detection of metabolic activity within the atherosclerotic lesions. Invasive imaging modalities such as intravascular ultrasound (IVUS), optical-coherence tomography (OCT), and intravascular MRI (IV-MRI) display plaques at a high spatial resolution. Near-infrared spectroscopy (NIRS) allows for the detection of chemical components of atherosclerotic plaques. In this review, we describe state-of-the-art non-invasive and invasive imaging modalities and stress the combination of their advantages to identify vulnerable plaque features.
AB - Vulnerable plaque is characterized by a large necrotic core and an overlying thin fibrous cap. Non-invasive imaging modalities such as computed tomography angiography (CTA) and magnetic resonance imaging (MRI) allow for the assessment of morphological plaque characteristics, while positron emission tomography (PET) enables the detection of metabolic activity within the atherosclerotic lesions. Invasive imaging modalities such as intravascular ultrasound (IVUS), optical-coherence tomography (OCT), and intravascular MRI (IV-MRI) display plaques at a high spatial resolution. Near-infrared spectroscopy (NIRS) allows for the detection of chemical components of atherosclerotic plaques. In this review, we describe state-of-the-art non-invasive and invasive imaging modalities and stress the combination of their advantages to identify vulnerable plaque features.
KW - Coronary artery disease
KW - Necrotic core
KW - Thin-cap fibroatheroma
KW - Vulnerable plaque
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UR - http://www.scopus.com/inward/citedby.url?scp=84962886272&partnerID=8YFLogxK
U2 - 10.1016/j.tcm.2016.03.005
DO - 10.1016/j.tcm.2016.03.005
M3 - Article
JO - Trends in Cardiovascular Medicine
JF - Trends in Cardiovascular Medicine
SN - 1050-1738
ER -