Non-insulin-dependent diabetic microangiopathy in the inner ear

Chapman T. Mcqueen, Andrew Baxter, Timothy Smith, Eileen Raynor, Sang Min Yoon, Jiri Prazma, Harold C. Pillsbury

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Hearing loss has long been associated with diabetes mellitus. Microangiopathy, associated with thickening of the basement membranes of small vessels, has been implicated as a major source of multiple system organ disease. Objective. This study was designed to evaluate changes in basement membrane thickness in the inner ear of laboratory animals suffering from non-insulin-dependent diabetes mellitus (NIDDM) with, and without, exposure to moderate intensity noise exposure in an attempt to extrapolate the same disease process in humans. Design. Spontaneously hypertensive-corpulent non-insulin-dependent rats (SHR/N-cp) were selected as a genetic model for the above study. Both lean and obese rats were used in this study. A genetically similar control group of animals (LA/N-cp) were used as controls. These animals express both the lean and obese phenotypes, but they lack the NIDDM, gene. Forty-eight animals in each group were sacrificed at the end of the study. The cochleas were dissected and fixed. The basement membrane of the stria vascularis was examined using transmission electron microscopy. Setting. This study was a laboratory-based, standard animal study. Main outcome. This study was designed to show microangiography of the inner ear as related to NIDDM with, and without, obesity and noise exposure. Results/Conclusions. NIDDM alone does not cause statistically significant basement membrane thickening; however, NIDDM in combination with obesity and/or noise exposure did show significant thickening and the combination of all three showed the greatest thickening. NIDDM appeared to be the greatest contributing factor.

Original languageEnglish (US)
Pages (from-to)13-18
Number of pages6
JournalJournal of Laryngology and Otology
Volume113
Issue number1
StatePublished - 1999
Externally publishedYes

Fingerprint

Diabetic Angiopathies
Inner Ear
Type 2 Diabetes Mellitus
Basement Membrane
Noise
Obesity
Stria Vascularis
Genetic Models
Cochlea
Laboratory Animals
Inbred SHR Rats
Transmission Electron Microscopy
Hearing Loss
Diabetes Mellitus
Phenotype
Control Groups
Genes

Keywords

  • Cochlea
  • Diabetes mellitus
  • Diabetic angiopathier
  • Non-insulin-dependent
  • Rats

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Mcqueen, C. T., Baxter, A., Smith, T., Raynor, E., Yoon, S. M., Prazma, J., & Pillsbury, H. C. (1999). Non-insulin-dependent diabetic microangiopathy in the inner ear. Journal of Laryngology and Otology, 113(1), 13-18.

Non-insulin-dependent diabetic microangiopathy in the inner ear. / Mcqueen, Chapman T.; Baxter, Andrew; Smith, Timothy; Raynor, Eileen; Yoon, Sang Min; Prazma, Jiri; Pillsbury, Harold C.

In: Journal of Laryngology and Otology, Vol. 113, No. 1, 1999, p. 13-18.

Research output: Contribution to journalArticle

Mcqueen, CT, Baxter, A, Smith, T, Raynor, E, Yoon, SM, Prazma, J & Pillsbury, HC 1999, 'Non-insulin-dependent diabetic microangiopathy in the inner ear', Journal of Laryngology and Otology, vol. 113, no. 1, pp. 13-18.
Mcqueen CT, Baxter A, Smith T, Raynor E, Yoon SM, Prazma J et al. Non-insulin-dependent diabetic microangiopathy in the inner ear. Journal of Laryngology and Otology. 1999;113(1):13-18.
Mcqueen, Chapman T. ; Baxter, Andrew ; Smith, Timothy ; Raynor, Eileen ; Yoon, Sang Min ; Prazma, Jiri ; Pillsbury, Harold C. / Non-insulin-dependent diabetic microangiopathy in the inner ear. In: Journal of Laryngology and Otology. 1999 ; Vol. 113, No. 1. pp. 13-18.
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