Non-heme manganese catalase - The 'other' catalase

James Whittaker

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Non-heme manganese catalases are widely distributed over microbial life and represent an environmentally important alternative to heme-containing catalases in antioxidant defense. Manganese catalases contain a binuclear manganese complex as their catalytic active site rather than a heme, and cycle between Mn 2(II,II) and Mn 2(III,III) states during turnover. X-ray crystallography has revealed the key structural elements of the binuclear manganese active site complex that can serve as the starting point for computational studies on the protein. Four manganese catalase enzymes have been isolated and characterized, and the enzyme appears to have a broad phylogenetic distribution including both bacteria and archae. More than 100 manganese catalase genes have been annotated in genomic databases, although the assignment of many of these putative manganese catalases needs to be experimentally verified. Iron limitation, exposure to low levels of peroxide stress, thermostability and cyanide resistance may provide the biological and environmental context for the occurrence of manganese catalases.

Original languageEnglish (US)
Pages (from-to)111-120
Number of pages10
JournalArchives of Biochemistry and Biophysics
Volume525
Issue number2
DOIs
StatePublished - Sep 15 2012

Fingerprint

Catalase
Catalytic Domain
Manganese
Heme
X ray crystallography
X Ray Crystallography
Peroxides
Cyanides
Enzymes
Bacteria
Iron
Antioxidants
Genes
Databases
Proteins

Keywords

  • Antioxidant
  • Catalase
  • Manganese
  • Oxidative stress
  • Peroxide
  • Reactive oxygen species

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Non-heme manganese catalase - The 'other' catalase. / Whittaker, James.

In: Archives of Biochemistry and Biophysics, Vol. 525, No. 2, 15.09.2012, p. 111-120.

Research output: Contribution to journalArticle

Whittaker, James. / Non-heme manganese catalase - The 'other' catalase. In: Archives of Biochemistry and Biophysics. 2012 ; Vol. 525, No. 2. pp. 111-120.
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