Non-hematopoietic control of peripheral tissue t cell responses

Implications for solid tumors

Ryan S. Lane, Amanda Lund

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

In response to pathological challenge, the host generates rapid, protective adaptive immune responses while simultaneously maintaining tolerance to self and limiting immune pathology. Peripheral tissues (e.g., skin, gut, lung) are simultaneously the first site of pathogen-encounter and also the location of effector function, and mounting evidence indicates that tissues act as scaffolds to facilitate initiation, maintenance, and resolution of local responses. Just as both effector and memory T cells must adapt to their new interstitial environment upon infiltration, tissues are also remodeled in the context of acute inflammation and disease. In this review, we present the biochemical and biophysical mechanisms by which non-hematopoietic stromal cells and extracellular matrix molecules collaborate to regulate T cell behavior in peripheral tissue. Finally, we discuss how tissue remodeling in the context of tumor microenvironments impairs T cell accumulation and function contributing to immune escape and tumor progression.

Original languageEnglish (US)
Article number2662
JournalFrontiers in Immunology
Volume9
Issue numberNOV
DOIs
StatePublished - Nov 15 2018

Fingerprint

Neoplasms
T-Lymphocytes
Tumor Escape
Tumor Microenvironment
Adaptive Immunity
Acute Disease
Stromal Cells
Extracellular Matrix
Maintenance
Pathology
Inflammation
Lung
Skin

Keywords

  • extravasation
  • fluid flow
  • immunotherapy
  • interstitial migration
  • non-hematopoietic cells
  • T cell
  • trafficking

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Non-hematopoietic control of peripheral tissue t cell responses : Implications for solid tumors. / Lane, Ryan S.; Lund, Amanda.

In: Frontiers in Immunology, Vol. 9, No. NOV, 2662, 15.11.2018.

Research output: Contribution to journalReview article

@article{22e53aca37f74c89bbd3f15b8736c343,
title = "Non-hematopoietic control of peripheral tissue t cell responses: Implications for solid tumors",
abstract = "In response to pathological challenge, the host generates rapid, protective adaptive immune responses while simultaneously maintaining tolerance to self and limiting immune pathology. Peripheral tissues (e.g., skin, gut, lung) are simultaneously the first site of pathogen-encounter and also the location of effector function, and mounting evidence indicates that tissues act as scaffolds to facilitate initiation, maintenance, and resolution of local responses. Just as both effector and memory T cells must adapt to their new interstitial environment upon infiltration, tissues are also remodeled in the context of acute inflammation and disease. In this review, we present the biochemical and biophysical mechanisms by which non-hematopoietic stromal cells and extracellular matrix molecules collaborate to regulate T cell behavior in peripheral tissue. Finally, we discuss how tissue remodeling in the context of tumor microenvironments impairs T cell accumulation and function contributing to immune escape and tumor progression.",
keywords = "extravasation, fluid flow, immunotherapy, interstitial migration, non-hematopoietic cells, T cell, trafficking",
author = "Lane, {Ryan S.} and Amanda Lund",
year = "2018",
month = "11",
day = "15",
doi = "10.3389/fimmu.2018.02662",
language = "English (US)",
volume = "9",
journal = "Frontiers in Immunology",
issn = "1664-3224",
publisher = "Frontiers Media S. A.",
number = "NOV",

}

TY - JOUR

T1 - Non-hematopoietic control of peripheral tissue t cell responses

T2 - Implications for solid tumors

AU - Lane, Ryan S.

AU - Lund, Amanda

PY - 2018/11/15

Y1 - 2018/11/15

N2 - In response to pathological challenge, the host generates rapid, protective adaptive immune responses while simultaneously maintaining tolerance to self and limiting immune pathology. Peripheral tissues (e.g., skin, gut, lung) are simultaneously the first site of pathogen-encounter and also the location of effector function, and mounting evidence indicates that tissues act as scaffolds to facilitate initiation, maintenance, and resolution of local responses. Just as both effector and memory T cells must adapt to their new interstitial environment upon infiltration, tissues are also remodeled in the context of acute inflammation and disease. In this review, we present the biochemical and biophysical mechanisms by which non-hematopoietic stromal cells and extracellular matrix molecules collaborate to regulate T cell behavior in peripheral tissue. Finally, we discuss how tissue remodeling in the context of tumor microenvironments impairs T cell accumulation and function contributing to immune escape and tumor progression.

AB - In response to pathological challenge, the host generates rapid, protective adaptive immune responses while simultaneously maintaining tolerance to self and limiting immune pathology. Peripheral tissues (e.g., skin, gut, lung) are simultaneously the first site of pathogen-encounter and also the location of effector function, and mounting evidence indicates that tissues act as scaffolds to facilitate initiation, maintenance, and resolution of local responses. Just as both effector and memory T cells must adapt to their new interstitial environment upon infiltration, tissues are also remodeled in the context of acute inflammation and disease. In this review, we present the biochemical and biophysical mechanisms by which non-hematopoietic stromal cells and extracellular matrix molecules collaborate to regulate T cell behavior in peripheral tissue. Finally, we discuss how tissue remodeling in the context of tumor microenvironments impairs T cell accumulation and function contributing to immune escape and tumor progression.

KW - extravasation

KW - fluid flow

KW - immunotherapy

KW - interstitial migration

KW - non-hematopoietic cells

KW - T cell

KW - trafficking

UR - http://www.scopus.com/inward/record.url?scp=85057358716&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85057358716&partnerID=8YFLogxK

U2 - 10.3389/fimmu.2018.02662

DO - 10.3389/fimmu.2018.02662

M3 - Review article

VL - 9

JO - Frontiers in Immunology

JF - Frontiers in Immunology

SN - 1664-3224

IS - NOV

M1 - 2662

ER -