Non-dopaminergic therapies

John Nutt, Nicolaas I. Bohnen

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Currently all aspects of Parkinson's disease (PD) treatment are less than ideal and would benefit from new interventions. We focus on problems associated with brain neurotransmitters amenable to more specific subreceptor and temporal manipulation. In addition, we consider potentially treatable CNS non-PD co-pathologies or co-morbidities that may exacerbate progression of various aspects of PD.

Original languageEnglish (US)
Pages (from-to)S73-S78
JournalJournal of Parkinson's Disease
Volume8
Issue numbers1
DOIs
StatePublished - Jan 1 2018

Fingerprint

Parkinson Disease
Neurotransmitter Agents
Pathology
Morbidity
Brain
Therapeutics

Keywords

  • Acetylcholine
  • Cognition
  • Diabetes mellitus
  • Falls
  • Freezing of gait
  • GABA
  • GBA
  • Glymphatic clearance
  • Small vessel disease
  • β-amyloid

ASJC Scopus subject areas

  • Clinical Neurology
  • Cellular and Molecular Neuroscience

Cite this

Non-dopaminergic therapies. / Nutt, John; Bohnen, Nicolaas I.

In: Journal of Parkinson's Disease, Vol. 8, No. s1, 01.01.2018, p. S73-S78.

Research output: Contribution to journalReview article

Nutt, John ; Bohnen, Nicolaas I. / Non-dopaminergic therapies. In: Journal of Parkinson's Disease. 2018 ; Vol. 8, No. s1. pp. S73-S78.
@article{6314d43d0bb64d53b386287edcc671b3,
title = "Non-dopaminergic therapies",
abstract = "Currently all aspects of Parkinson's disease (PD) treatment are less than ideal and would benefit from new interventions. We focus on problems associated with brain neurotransmitters amenable to more specific subreceptor and temporal manipulation. In addition, we consider potentially treatable CNS non-PD co-pathologies or co-morbidities that may exacerbate progression of various aspects of PD.",
keywords = "Acetylcholine, Cognition, Diabetes mellitus, Falls, Freezing of gait, GABA, GBA, Glymphatic clearance, Small vessel disease, β-amyloid",
author = "John Nutt and Bohnen, {Nicolaas I.}",
year = "2018",
month = "1",
day = "1",
doi = "10.3233/JPD-181472",
language = "English (US)",
volume = "8",
pages = "S73--S78",
journal = "Journal of Parkinson's Disease",
issn = "1877-7171",
publisher = "IOS Press",
number = "s1",

}

TY - JOUR

T1 - Non-dopaminergic therapies

AU - Nutt, John

AU - Bohnen, Nicolaas I.

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Currently all aspects of Parkinson's disease (PD) treatment are less than ideal and would benefit from new interventions. We focus on problems associated with brain neurotransmitters amenable to more specific subreceptor and temporal manipulation. In addition, we consider potentially treatable CNS non-PD co-pathologies or co-morbidities that may exacerbate progression of various aspects of PD.

AB - Currently all aspects of Parkinson's disease (PD) treatment are less than ideal and would benefit from new interventions. We focus on problems associated with brain neurotransmitters amenable to more specific subreceptor and temporal manipulation. In addition, we consider potentially treatable CNS non-PD co-pathologies or co-morbidities that may exacerbate progression of various aspects of PD.

KW - Acetylcholine

KW - Cognition

KW - Diabetes mellitus

KW - Falls

KW - Freezing of gait

KW - GABA

KW - GBA

KW - Glymphatic clearance

KW - Small vessel disease

KW - β-amyloid

UR - http://www.scopus.com/inward/record.url?scp=85058864876&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85058864876&partnerID=8YFLogxK

U2 - 10.3233/JPD-181472

DO - 10.3233/JPD-181472

M3 - Review article

C2 - 30584157

AN - SCOPUS:85058864876

VL - 8

SP - S73-S78

JO - Journal of Parkinson's Disease

JF - Journal of Parkinson's Disease

SN - 1877-7171

IS - s1

ER -