Abstract
Beginning in 1983, 71 girls with Turner syndrome were enrolled in a prospective, randomized study of human growth hormone (hGH), alone and in combination with oxandrolone; 4-5 patient-year data are currently available on 66 subjects. While the annual growth rate of the untreated control group (expressed as a Z score for untreated Turner girls) was -0.1 SD, the annual Turner growth rate Z scores for girls receiving hGH alone were +3.1, +2.0, +1.5 and +2.9 SD for years 1-4, respectively (hGH was given daily in year 4). Mean annual Turner growth rate Z scores for subjects on combination therapy with oxandrolone were +6.6, +4.3, +3.0 and +2.7 SD for years 1-4, respectively. The mean height for the 20 subjects ≥ 16 years of age is 150 cm.
Original language | English (US) |
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Pages (from-to) | 137-143 |
Number of pages | 7 |
Journal | Hormone Research |
Volume | 33 |
Issue number | 2-4 |
DOIs | |
State | Published - 1990 |
Externally published | Yes |
Keywords
- Turner syndrome
- growth
- growth hormone
- short stature
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Endocrinology