Non-conventional growth hormone therapy in Turner syndrome: the United States experience

R. G. Rosenfeld

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Beginning in 1983, 71 girls with Turner syndrome were enrolled in a prospective, randomized study of human growth hormone (hGH), alone and in combination with oxandrolone; 4-5 patient-year data are currently available on 66 subjects. While the annual growth rate of the untreated control group (expressed as a Z score for untreated Turner girls) was -0.1 SD, the annual Turner growth rate Z scores for girls receiving hGH alone were +3.1, +2.0, +1.5 and +2.9 SD for years 1-4, respectively (hGH was given daily in year 4). Mean annual Turner growth rate Z scores for subjects on combination therapy with oxandrolone were +6.6, +4.3, +3.0 and +2.7 SD for years 1-4, respectively. The mean height for the 20 subjects ≥ 16 years of age is 150 cm.

Original languageEnglish (US)
Pages (from-to)137-143
Number of pages7
JournalHormone Research
Volume33
Issue number2-4
DOIs
StatePublished - Jan 1 1990

Keywords

  • Turner syndrome
  • growth
  • growth hormone
  • short stature

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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