Abstract
Conflicting investigations regarding the potential protective effect of melanin against noise-induced sensorineural hearing loss have suggested that eumelanin and pheomelanin may have differing effects within the stria vascularis. Three strains of C57BL/6J mice, (+/+, a/a) wild-types (dark coats/black eyes), (c2j/c2j, a/a), albinos (white coats/pink eyes), and (+/+, Ay/Ay) yellow mice (yellow coats/black eyes), were subjected to five consecutive days of broad band noise exposure at 112 dB(A) SPL for 3 h/day. Cochlear function was evaluated with auditory brainstem response audiometry to pure tones immediately pre-exposure, 5-6 h post-exposure, and 14 days post-exposure. No significant difference in the degree of sensorineural hearing loss induced in the three strains of mice was identified. The eumelanin and pheomelanin content of each stria vascularis and amount of protein per stria for both mouse and guinea pig (2/NCR) were determined via high performance liquid chromatography. No pheomelanin was found in the stria of yellow mice, suggesting that coat color is not an accurate predictor of strial melanin content. The melanin content per mg of strial protein was higher in mice than in guinea pigs. A species-specific difference in melanin content does not explain the absence of a protective effect in mice.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 116-123 |
| Number of pages | 8 |
| Journal | Hearing Research |
| Volume | 154 |
| Issue number | 1-2 |
| DOIs | |
| State | Published - 2001 |
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Keywords
- Melanin
- Pigment
- Sensorineural
- Stria vascularis
ASJC Scopus subject areas
- Sensory Systems
Cite this
Noise-induced hearing loss : The effect of melanin in the stria vascularis. / Bartels, Sande; Ito, Shosuke; Trune, Dennis; Nuttall, Alfred.
In: Hearing Research, Vol. 154, No. 1-2, 2001, p. 116-123.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Noise-induced hearing loss
T2 - The effect of melanin in the stria vascularis
AU - Bartels, Sande
AU - Ito, Shosuke
AU - Trune, Dennis
AU - Nuttall, Alfred
PY - 2001
Y1 - 2001
N2 - Conflicting investigations regarding the potential protective effect of melanin against noise-induced sensorineural hearing loss have suggested that eumelanin and pheomelanin may have differing effects within the stria vascularis. Three strains of C57BL/6J mice, (+/+, a/a) wild-types (dark coats/black eyes), (c2j/c2j, a/a), albinos (white coats/pink eyes), and (+/+, Ay/Ay) yellow mice (yellow coats/black eyes), were subjected to five consecutive days of broad band noise exposure at 112 dB(A) SPL for 3 h/day. Cochlear function was evaluated with auditory brainstem response audiometry to pure tones immediately pre-exposure, 5-6 h post-exposure, and 14 days post-exposure. No significant difference in the degree of sensorineural hearing loss induced in the three strains of mice was identified. The eumelanin and pheomelanin content of each stria vascularis and amount of protein per stria for both mouse and guinea pig (2/NCR) were determined via high performance liquid chromatography. No pheomelanin was found in the stria of yellow mice, suggesting that coat color is not an accurate predictor of strial melanin content. The melanin content per mg of strial protein was higher in mice than in guinea pigs. A species-specific difference in melanin content does not explain the absence of a protective effect in mice.
AB - Conflicting investigations regarding the potential protective effect of melanin against noise-induced sensorineural hearing loss have suggested that eumelanin and pheomelanin may have differing effects within the stria vascularis. Three strains of C57BL/6J mice, (+/+, a/a) wild-types (dark coats/black eyes), (c2j/c2j, a/a), albinos (white coats/pink eyes), and (+/+, Ay/Ay) yellow mice (yellow coats/black eyes), were subjected to five consecutive days of broad band noise exposure at 112 dB(A) SPL for 3 h/day. Cochlear function was evaluated with auditory brainstem response audiometry to pure tones immediately pre-exposure, 5-6 h post-exposure, and 14 days post-exposure. No significant difference in the degree of sensorineural hearing loss induced in the three strains of mice was identified. The eumelanin and pheomelanin content of each stria vascularis and amount of protein per stria for both mouse and guinea pig (2/NCR) were determined via high performance liquid chromatography. No pheomelanin was found in the stria of yellow mice, suggesting that coat color is not an accurate predictor of strial melanin content. The melanin content per mg of strial protein was higher in mice than in guinea pigs. A species-specific difference in melanin content does not explain the absence of a protective effect in mice.
KW - Melanin
KW - Pigment
KW - Sensorineural
KW - Stria vascularis
UR - http://www.scopus.com/inward/record.url?scp=0034989695&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034989695&partnerID=8YFLogxK
U2 - 10.1016/S0378-5955(01)00213-1
DO - 10.1016/S0378-5955(01)00213-1
M3 - Article
VL - 154
SP - 116
EP - 123
JO - Hearing Research
JF - Hearing Research
SN - 0378-5955
IS - 1-2
ER -