Nocturnal Hypoglycemia as a Cause of Fasting Hyperglycemia (Somogyi Phenomenon)

P. Barton Duell; Deborah Rotenstein; Sigmund R. Greenberg; Karen M. Tordjman; Carolyn E. Havlin; Lucy A. Levandoski; Neil H. White; Julio V. Santiago; Philip E. Cryer

doi:10.1056/NEJM198806093182311

Nocturnal Hypoglycemia as a Cause of Fasting Hyperglycemia (Somogyi Phenomenon)

P. Barton Duell, Deborah Rotenstein, Sigmund R. Greenberg, Karen M. Tordjman, Carolyn E. Havlin, Lucy A. Levandoski, Neil H. White, Julio V. Santiago, Philip E. Cryer

Research output: Contribution to journal › Letter › peer-review

Abstract

To the Editor: Tordjman and colleagues (Dec. 17 issue)¹ reported a well-designed investigation of the effects of nocturnal hypoglycemia on fasting plasma glucose concentrations in patients with insulin-dependent diabetes mellitus (IDDM). Their data, as interpreted by the authors, challenge the traditional clinical logic of many physicians and suggest that the Somogyi phenomenon may rarely, if ever, cause clinically important fasting hyperglycemia in patients with IDDM. Although their conclusions are well justified, several aspects of the methods used potentially limit the applicability of these findings to every patient with IDDM. First, the patients selected for study had relatively well-controlled IDDM (mean.

Original language	English (US)
Pages (from-to)	1537-1538
Number of pages	2
Journal	New England Journal of Medicine
Volume	318
Issue number	23
DOIs	https://doi.org/10.1056/NEJM198806093182311
State	Published - Jun 9 1988
Externally published	Yes

ASJC Scopus subject areas

Medicine(all)

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title = "Nocturnal Hypoglycemia as a Cause of Fasting Hyperglycemia (Somogyi Phenomenon)",

abstract = "To the Editor: Tordjman and colleagues (Dec. 17 issue)1 reported a well-designed investigation of the effects of nocturnal hypoglycemia on fasting plasma glucose concentrations in patients with insulin-dependent diabetes mellitus (IDDM). Their data, as interpreted by the authors, challenge the traditional clinical logic of many physicians and suggest that the Somogyi phenomenon may rarely, if ever, cause clinically important fasting hyperglycemia in patients with IDDM. Although their conclusions are well justified, several aspects of the methods used potentially limit the applicability of these findings to every patient with IDDM. First, the patients selected for study had relatively well-controlled IDDM (mean.",

author = "Duell, {P. Barton} and Deborah Rotenstein and Greenberg, {Sigmund R.} and Tordjman, {Karen M.} and Havlin, {Carolyn E.} and Levandoski, {Lucy A.} and White, {Neil H.} and Santiago, {Julio V.} and Cryer, {Philip E.}",

year = "1988",

month = jun,

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doi = "10.1056/NEJM198806093182311",

language = "English (US)",

volume = "318",

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journal = "New England Journal of Medicine",

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T1 - Nocturnal Hypoglycemia as a Cause of Fasting Hyperglycemia (Somogyi Phenomenon)

AU - Duell, P. Barton

AU - Rotenstein, Deborah

AU - Greenberg, Sigmund R.

AU - Tordjman, Karen M.

AU - Havlin, Carolyn E.

AU - Levandoski, Lucy A.

AU - White, Neil H.

AU - Santiago, Julio V.

AU - Cryer, Philip E.

PY - 1988/6/9

Y1 - 1988/6/9

N2 - To the Editor: Tordjman and colleagues (Dec. 17 issue)1 reported a well-designed investigation of the effects of nocturnal hypoglycemia on fasting plasma glucose concentrations in patients with insulin-dependent diabetes mellitus (IDDM). Their data, as interpreted by the authors, challenge the traditional clinical logic of many physicians and suggest that the Somogyi phenomenon may rarely, if ever, cause clinically important fasting hyperglycemia in patients with IDDM. Although their conclusions are well justified, several aspects of the methods used potentially limit the applicability of these findings to every patient with IDDM. First, the patients selected for study had relatively well-controlled IDDM (mean.

AB - To the Editor: Tordjman and colleagues (Dec. 17 issue)1 reported a well-designed investigation of the effects of nocturnal hypoglycemia on fasting plasma glucose concentrations in patients with insulin-dependent diabetes mellitus (IDDM). Their data, as interpreted by the authors, challenge the traditional clinical logic of many physicians and suggest that the Somogyi phenomenon may rarely, if ever, cause clinically important fasting hyperglycemia in patients with IDDM. Although their conclusions are well justified, several aspects of the methods used potentially limit the applicability of these findings to every patient with IDDM. First, the patients selected for study had relatively well-controlled IDDM (mean.

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Nocturnal Hypoglycemia as a Cause of Fasting Hyperglycemia (Somogyi Phenomenon)

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