No evidence for mutations in a putative β-cell ATP-sensitive K+ channel subunit in MODY, NIDDM, or GDM

Yun Zhang, Margaret Warren-Perry, Hiroshi Sakura, John Adelman, Markus Stoffel, Graeme I. Bell, Frances M. Ashcroft, Robert C. Turner

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The β-cell ATP-sensitive K+ (K-ATP) channel has a major role in glucose- induced insulin secretion. Screening the entire coding sequence of the gene for a putative β-cell K-ATP channel subunit, K-ATP2, with single-strand conformation polymorphism did not show any mutations associated with diabetes in white Caucasian diabetic patients, including five pedigrees with maturity onset diabetes of the young (MODY), 25 patients with non-insulin-dependent diabetes mellitus (NIDDM) selected for marked β-cell deficiency, 25 selected for mild diabetes presenting before age 50 years with fasting plasma glucose levels

Original languageEnglish (US)
Pages (from-to)597-600
Number of pages4
JournalDiabetes
Volume44
Issue number5
StatePublished - 1995

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Type 2 Diabetes Mellitus
Adenosine Triphosphate
Mutation
Glucose
Pedigree
Fasting
Insulin
Genes
Mason-Type Diabetes

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Zhang, Y., Warren-Perry, M., Sakura, H., Adelman, J., Stoffel, M., Bell, G. I., ... Turner, R. C. (1995). No evidence for mutations in a putative β-cell ATP-sensitive K+ channel subunit in MODY, NIDDM, or GDM. Diabetes, 44(5), 597-600.

No evidence for mutations in a putative β-cell ATP-sensitive K+ channel subunit in MODY, NIDDM, or GDM. / Zhang, Yun; Warren-Perry, Margaret; Sakura, Hiroshi; Adelman, John; Stoffel, Markus; Bell, Graeme I.; Ashcroft, Frances M.; Turner, Robert C.

In: Diabetes, Vol. 44, No. 5, 1995, p. 597-600.

Research output: Contribution to journalArticle

Zhang, Y, Warren-Perry, M, Sakura, H, Adelman, J, Stoffel, M, Bell, GI, Ashcroft, FM & Turner, RC 1995, 'No evidence for mutations in a putative β-cell ATP-sensitive K+ channel subunit in MODY, NIDDM, or GDM', Diabetes, vol. 44, no. 5, pp. 597-600.
Zhang Y, Warren-Perry M, Sakura H, Adelman J, Stoffel M, Bell GI et al. No evidence for mutations in a putative β-cell ATP-sensitive K+ channel subunit in MODY, NIDDM, or GDM. Diabetes. 1995;44(5):597-600.
Zhang, Yun ; Warren-Perry, Margaret ; Sakura, Hiroshi ; Adelman, John ; Stoffel, Markus ; Bell, Graeme I. ; Ashcroft, Frances M. ; Turner, Robert C. / No evidence for mutations in a putative β-cell ATP-sensitive K+ channel subunit in MODY, NIDDM, or GDM. In: Diabetes. 1995 ; Vol. 44, No. 5. pp. 597-600.
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