NMDA receptors in mice bred to be prone or resistant to ethanol withdrawal seizures

Peter Valverius, John C. Crabbe, Paula L. Hoffman, Boris Tabakoff

Research output: Contribution to journalArticle

60 Scopus citations

Abstract

Selective breeding has produced replicate lines of mice that are prone (WSP) or resistant (WSR) to ethanol withdrawal seizures. Ethanol-naive WSP mice inherently have a greater number of hippocampal binding sites for the NMDA receptor-gated ion channel blocker, MK-801, than ethanol-naive WSR mice. After chronic ethanol ingestion, hippocampal (but not cerebral cortical) MK-801 binding sites increase in both lines of mice. However, the number of MK-801 binding sites in the ethanol-treated WSR mice does not exceed the number of MK-801 binding sites in untreated WSP mice. At the time of ethanol withdrawal, the number of hippocampal MK-801 binding sites in each line of WSP mice is 50-70% higher than the number of such sites in WSR mice. Given the past evidence for a role of the NMDA receptor in seizures, the results implicate hippocampal NMDA receptor-gated channels in the generation of ethanol withdrawal seizures.

Original languageEnglish (US)
Pages (from-to)185-189
Number of pages5
JournalEuropean Journal of Pharmacology
Volume184
Issue number1
DOIs
StatePublished - Aug 2 1990

Keywords

  • (Selected mouse lines)
  • Ethanol withdrawal seizures
  • Genetics
  • MK-801 binding
  • NMDA receptors
  • Pharmacogenetics

ASJC Scopus subject areas

  • Pharmacology

Fingerprint Dive into the research topics of 'NMDA receptors in mice bred to be prone or resistant to ethanol withdrawal seizures'. Together they form a unique fingerprint.

  • Cite this