NMDA receptor kinetics and synaptic function

Craig Jahr

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Presynaptic release of L-glutamate mediates neurotransmission at most excitatory synapses in the vertebrate central nervous system. At the postsynaptic membrane, glutamate binds to two classes of ligand-gated ion channels, AMPA receptors and NMDA receptors. These channels are the basis of the two kinetically distinct components of the excitatory postsynaptic current (epsc). The slower synaptic conductance is mediated by NMDA receptor channels which, after binding glutamate, activate slowly and can remain activated for several hundred milliseconds. The average latency between glutamate binding and channel opening is at least several milliseconds and may be much longer. If the time to first opening is short many fewer channels would be required at each synaptic site to account for the amplitude of the NMDA receptor component of spontaneous miniature epscs, than if the time to first opening is very long.

Original languageEnglish (US)
Pages (from-to)81-86
Number of pages6
JournalSeminars in Neuroscience
Volume6
Issue number2
DOIs
Publication statusPublished - Apr 1994

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Keywords

  • excitatory postsynaptic currents/first latency distribution/glutamate/NMDA receptor/open probability

ASJC Scopus subject areas

  • Neuroscience(all)

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