NLGN3/NLGN4 gene mutations are not responsible for autism in the Quebec population

Julie Gauthier, Anna Bonnel, Judith St-Onge, Liliane Karemera, Sandra Laurent, Laurent Mottron, Eric Fombonne, Ridha Joober, Guy A. Rouleau

Research output: Contribution to journalArticle

94 Citations (Scopus)

Abstract

Jamain [2003: Nat Genet 34:27-29] recently reported mutations in two neuroligin genes in sib-pairs affected with autism. In order to confirm these causative mutations in our autistic population and to determine their frequency we screened 96 individuals affected with autism. We found no mutations in these X-linked genes. These results indicate that mutations in NLGN3 and NLGN4 genes are responsible for at most a small fraction of autism cases and additional screenings in other autistic populations are needed to better determine the frequency with which mutations in NLGN3 and NLGN4 occur in autism.

Original languageEnglish (US)
Pages (from-to)74-75
Number of pages2
JournalAmerican Journal of Medical Genetics - Neuropsychiatric Genetics
Volume132 B
Issue number1
DOIs
StatePublished - Jan 5 2005
Externally publishedYes

Fingerprint

Quebec
Autistic Disorder
Mutation
Population
Genes
Viverridae
X-Linked Genes

Keywords

  • Autism
  • Neuroligin
  • X-chromosome

ASJC Scopus subject areas

  • Genetics(clinical)
  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)

Cite this

Gauthier, J., Bonnel, A., St-Onge, J., Karemera, L., Laurent, S., Mottron, L., ... Rouleau, G. A. (2005). NLGN3/NLGN4 gene mutations are not responsible for autism in the Quebec population. American Journal of Medical Genetics - Neuropsychiatric Genetics, 132 B(1), 74-75. https://doi.org/10.1002/ajmg.b.30066

NLGN3/NLGN4 gene mutations are not responsible for autism in the Quebec population. / Gauthier, Julie; Bonnel, Anna; St-Onge, Judith; Karemera, Liliane; Laurent, Sandra; Mottron, Laurent; Fombonne, Eric; Joober, Ridha; Rouleau, Guy A.

In: American Journal of Medical Genetics - Neuropsychiatric Genetics, Vol. 132 B, No. 1, 05.01.2005, p. 74-75.

Research output: Contribution to journalArticle

Gauthier, J, Bonnel, A, St-Onge, J, Karemera, L, Laurent, S, Mottron, L, Fombonne, E, Joober, R & Rouleau, GA 2005, 'NLGN3/NLGN4 gene mutations are not responsible for autism in the Quebec population', American Journal of Medical Genetics - Neuropsychiatric Genetics, vol. 132 B, no. 1, pp. 74-75. https://doi.org/10.1002/ajmg.b.30066
Gauthier, Julie ; Bonnel, Anna ; St-Onge, Judith ; Karemera, Liliane ; Laurent, Sandra ; Mottron, Laurent ; Fombonne, Eric ; Joober, Ridha ; Rouleau, Guy A. / NLGN3/NLGN4 gene mutations are not responsible for autism in the Quebec population. In: American Journal of Medical Genetics - Neuropsychiatric Genetics. 2005 ; Vol. 132 B, No. 1. pp. 74-75.
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