NLGN3/NLGN4 gene mutations are not responsible for autism in the Quebec population

Julie Gauthier; Anna Bonnel; Judith St-Onge; Liliane Karemera; Sandra Laurent; Laurent Mottron; Éric Fombonne; Ridha Joober; Guy A. Rouleau

doi:10.1002/ajmg.b.30066

NLGN3/NLGN4 gene mutations are not responsible for autism in the Quebec population

Julie Gauthier, Anna Bonnel, Judith St-Onge, Liliane Karemera, Sandra Laurent, Laurent Mottron, Éric Fombonne, Ridha Joober, Guy A. Rouleau

Research output: Contribution to journal › Article › peer-review

99 Scopus citations

Abstract

Jamain [2003: Nat Genet 34:27-29] recently reported mutations in two neuroligin genes in sib-pairs affected with autism. In order to confirm these causative mutations in our autistic population and to determine their frequency we screened 96 individuals affected with autism. We found no mutations in these X-linked genes. These results indicate that mutations in NLGN3 and NLGN4 genes are responsible for at most a small fraction of autism cases and additional screenings in other autistic populations are needed to better determine the frequency with which mutations in NLGN3 and NLGN4 occur in autism.

Original language	English (US)
Pages (from-to)	74-75
Number of pages	2
Journal	American Journal of Medical Genetics - Neuropsychiatric Genetics
Volume	132 B
Issue number	1
DOIs	https://doi.org/10.1002/ajmg.b.30066
State	Published - Jan 5 2005
Externally published	Yes

Keywords

Autism
Neuroligin
X-chromosome

ASJC Scopus subject areas

Genetics(clinical)
Psychiatry and Mental health
Cellular and Molecular Neuroscience

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10.1002/ajmg.b.30066

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abstract = "Jamain [2003: Nat Genet 34:27-29] recently reported mutations in two neuroligin genes in sib-pairs affected with autism. In order to confirm these causative mutations in our autistic population and to determine their frequency we screened 96 individuals affected with autism. We found no mutations in these X-linked genes. These results indicate that mutations in NLGN3 and NLGN4 genes are responsible for at most a small fraction of autism cases and additional screenings in other autistic populations are needed to better determine the frequency with which mutations in NLGN3 and NLGN4 occur in autism.",

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T1 - NLGN3/NLGN4 gene mutations are not responsible for autism in the Quebec population

AU - Gauthier, Julie

AU - Bonnel, Anna

AU - St-Onge, Judith

AU - Karemera, Liliane

AU - Laurent, Sandra

AU - Mottron, Laurent

AU - Fombonne, Éric

AU - Joober, Ridha

AU - Rouleau, Guy A.

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N2 - Jamain [2003: Nat Genet 34:27-29] recently reported mutations in two neuroligin genes in sib-pairs affected with autism. In order to confirm these causative mutations in our autistic population and to determine their frequency we screened 96 individuals affected with autism. We found no mutations in these X-linked genes. These results indicate that mutations in NLGN3 and NLGN4 genes are responsible for at most a small fraction of autism cases and additional screenings in other autistic populations are needed to better determine the frequency with which mutations in NLGN3 and NLGN4 occur in autism.

AB - Jamain [2003: Nat Genet 34:27-29] recently reported mutations in two neuroligin genes in sib-pairs affected with autism. In order to confirm these causative mutations in our autistic population and to determine their frequency we screened 96 individuals affected with autism. We found no mutations in these X-linked genes. These results indicate that mutations in NLGN3 and NLGN4 genes are responsible for at most a small fraction of autism cases and additional screenings in other autistic populations are needed to better determine the frequency with which mutations in NLGN3 and NLGN4 occur in autism.

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KW - Neuroligin

KW - X-chromosome

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NLGN3/NLGN4 gene mutations are not responsible for autism in the Quebec population

Abstract

Keywords

ASJC Scopus subject areas

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