NLGN3/NLGN4 gene mutations are not responsible for autism in the Quebec population

Julie Gauthier, Anna Bonnel, Judith St-Onge, Liliane Karemera, Sandra Laurent, Laurent Mottron, Éric Fombonne, Ridha Joober, Guy A. Rouleau

Research output: Contribution to journalArticlepeer-review

98 Scopus citations


Jamain [2003: Nat Genet 34:27-29] recently reported mutations in two neuroligin genes in sib-pairs affected with autism. In order to confirm these causative mutations in our autistic population and to determine their frequency we screened 96 individuals affected with autism. We found no mutations in these X-linked genes. These results indicate that mutations in NLGN3 and NLGN4 genes are responsible for at most a small fraction of autism cases and additional screenings in other autistic populations are needed to better determine the frequency with which mutations in NLGN3 and NLGN4 occur in autism.

Original languageEnglish (US)
Pages (from-to)74-75
Number of pages2
JournalAmerican Journal of Medical Genetics - Neuropsychiatric Genetics
Volume132 B
Issue number1
StatePublished - Jan 5 2005
Externally publishedYes


  • Autism
  • Neuroligin
  • X-chromosome

ASJC Scopus subject areas

  • Genetics(clinical)
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience


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