Nitroglycerine promotes myocardial oxygen metabolism and regional cardiac function in vivo

Jian ping Bin, Dai-Trang (Elizabeth) Le, Shao min Chen, Dao gang Zha, Yi li Liu, Sanjiv Kaul

Research output: Contribution to journalArticle

Abstract

OBJECTIVE: To investigate the effects of nitroglycerine (NTG) on myocardial oxygen metabolism and regional cardiac function in canine hearts with a stable systemic hemodynamics in situ. METHODS: Eight anesthetized open-chest dogs with flow-limited left anterior descending branch of the coronary artery or left circumflex artery (LCx) stenosis were studied. The percentage of ventricular wall thickening (%WT) was measured with quantitative two-dimensional echocardiography (2DE), myocardial blood flow (MBF) with radiolabeled microspheres and tissue oxygen pressure (tPO(2).) with oxygen-dependent quenching of phosphorescence. 2DE was performed and radiolabeled microspheres and Pd-porphyrin injected in the dogs at rest during intracoronary infusion of 0.3-0.6 mg x kg(-1) x min(-1) of NTG. Myocardial oxygen consumption (MVO(2), ml x min(-1) x 100 g(-1)) was calculated as the multiplication product between the arterio-venous oxygen content difference and MBF, and myocardial O(2) delivery as the product between arterial oxygen content and MBF. RESULTS: As compared with the baseline, NTG increased %WT and MBF significantly in both normal and ischemic beds (P

Original languageEnglish (US)
Pages (from-to)423-426
Number of pages4
JournalNan fang yi ke da xue xue bao = Journal of Southern Medical University
Volume27
Issue number4
StatePublished - Apr 2007
Externally publishedYes

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Nitroglycerin
Oxygen
Microspheres
Dogs
Oxygen Consumption
Echocardiography
Canidae
Coronary Vessels
Pathologic Constriction
Thorax
Arteries
Hemodynamics
Pressure

ASJC Scopus subject areas

  • Medicine(all)

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Nitroglycerine promotes myocardial oxygen metabolism and regional cardiac function in vivo. / Bin, Jian ping; Le, Dai-Trang (Elizabeth); Chen, Shao min; Zha, Dao gang; Liu, Yi li; Kaul, Sanjiv.

In: Nan fang yi ke da xue xue bao = Journal of Southern Medical University, Vol. 27, No. 4, 04.2007, p. 423-426.

Research output: Contribution to journalArticle

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AU - Kaul, Sanjiv

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