Nitrogen Utilization from Elemental Diets

Jorge E. Albina, Danny Jacobs, George Melnik, R. Gregg Settle, T. Peter Stein, John L. Rombeau, David Guy

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Repletion experiments were performed in malnourished, chair-adapted primates to explore recently reported differences in nitrogen utilization from elemental diets. Two elemental diets were fed consecutively for 8 days through a gastrostomy. Diet C (maltodextrins, peptides, crystalline amino acids) resulted in: larger weight gain (F1,6 = 17.93, p < 0.01); smaller decrease of serum albumin (F1,5 = 11.2, p < 0.015), larger increase in total iron binding capacity (F1,6 = 30.6, p < 0.002), and a more positive nitrogen balance (F1,6 = 30.4, p < 0.002) than diet V (glucose oligosaccharides, crystalline amino acids). Diet C was considered to be more effective in the nutritional repletion of the study animals. Additional experiments were performed in normal human volunteers to investigate the metabolic fate of ingested glutamine and whether the rapid catabolism and excretion of the amido nitrogen of this amino acid, which constitutes 11.56% of total nitrogen in diet V, could explain the differences observed in primates in our study and in human subjects by other authors. Six normal volunteers were fed 15N amino glutamine, 15N alanine, or 15N H4Cl. Similar amounts of 15N from Gln and Ala were excreted in 10 hr. The amido group of glutamine does not seem to be metabolized differently from the α-amino group of alanine under the conditions of the study. The marked differences in nitrogen utilization from the study diets could not be explained by the presence of relatively large amounts of glutamine in one of them. (Journal of Parenteral and Enteral Nutrition 9:189-195, 1985).

Original languageEnglish (US)
Pages (from-to)189-195
Number of pages7
JournalJournal of Parenteral and Enteral Nutrition
Volume9
Issue number2
DOIs
StatePublished - Jan 1 1985
Externally publishedYes

Fingerprint

Formulated Food
Glutamine
Nitrogen
Diet
Amino Acids
Alanine
Primates
Healthy Volunteers
Gastrostomy
Parenteral Nutrition
Enteral Nutrition
Oligosaccharides
Serum Albumin
Weight Gain
Iron
Glucose
Peptides

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Albina, J. E., Jacobs, D., Melnik, G., Settle, R. G., Stein, T. P., Rombeau, J. L., & Guy, D. (1985). Nitrogen Utilization from Elemental Diets. Journal of Parenteral and Enteral Nutrition, 9(2), 189-195. https://doi.org/10.1177/0148607185009002189

Nitrogen Utilization from Elemental Diets. / Albina, Jorge E.; Jacobs, Danny; Melnik, George; Settle, R. Gregg; Stein, T. Peter; Rombeau, John L.; Guy, David.

In: Journal of Parenteral and Enteral Nutrition, Vol. 9, No. 2, 01.01.1985, p. 189-195.

Research output: Contribution to journalArticle

Albina, JE, Jacobs, D, Melnik, G, Settle, RG, Stein, TP, Rombeau, JL & Guy, D 1985, 'Nitrogen Utilization from Elemental Diets', Journal of Parenteral and Enteral Nutrition, vol. 9, no. 2, pp. 189-195. https://doi.org/10.1177/0148607185009002189
Albina, Jorge E. ; Jacobs, Danny ; Melnik, George ; Settle, R. Gregg ; Stein, T. Peter ; Rombeau, John L. ; Guy, David. / Nitrogen Utilization from Elemental Diets. In: Journal of Parenteral and Enteral Nutrition. 1985 ; Vol. 9, No. 2. pp. 189-195.
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