Nitric oxide synthesis is increased in patients with systemic lupus erythematosus

A. Wanchu; M. Khullar; S. D. Deodhar; P. Bambery; A. Sud

doi:10.1007/s002960050055

Nitric oxide synthesis is increased in patients with systemic lupus erythematosus

A. Wanchu, M. Khullar, S. D. Deodhar, P. Bambery, A. Sud

Research output: Contribution to journal › Article › peer-review

67 Scopus citations

Abstract

Nitric oxide (NO) is believed to have a role in the inflammatory process. NO production was measured in 26 patients with systemic lupus erythematosus (SLE) and 20 healthy volunteers, using spectrophotometrically determined serum nitrite and citrulline as surrogate markers. Both nitrite and citrulline levels were significantly higher in patients with SLE than in controls (P < 0.001). Twelve and 10 patients, respectively, with SLE had nitrite and citrulline levels that were two standard deviations higher than the mean level of controls. These patients had a significantly higher measure of disease activity (SLE Disease Activity Index). These data show that there is increased NO production in SLE and that it may serve as a marker for disease activity.

Original language	English (US)
Pages (from-to)	41-43
Number of pages	3
Journal	Rheumatology International
Volume	18
Issue number	2
DOIs	https://doi.org/10.1007/s002960050055
State	Published - 1998
Externally published	Yes

Keywords

Citrulline
Disease activity
Nitric oxide
Nitrite
Systemic lupus erythematosus

ASJC Scopus subject areas

Immunology and Allergy
Rheumatology
Immunology

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10.1007/s002960050055

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title = "Nitric oxide synthesis is increased in patients with systemic lupus erythematosus",

abstract = "Nitric oxide (NO) is believed to have a role in the inflammatory process. NO production was measured in 26 patients with systemic lupus erythematosus (SLE) and 20 healthy volunteers, using spectrophotometrically determined serum nitrite and citrulline as surrogate markers. Both nitrite and citrulline levels were significantly higher in patients with SLE than in controls (P < 0.001). Twelve and 10 patients, respectively, with SLE had nitrite and citrulline levels that were two standard deviations higher than the mean level of controls. These patients had a significantly higher measure of disease activity (SLE Disease Activity Index). These data show that there is increased NO production in SLE and that it may serve as a marker for disease activity.",

keywords = "Citrulline, Disease activity, Nitric oxide, Nitrite, Systemic lupus erythematosus",

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T1 - Nitric oxide synthesis is increased in patients with systemic lupus erythematosus

AU - Wanchu, A.

AU - Khullar, M.

AU - Deodhar, S. D.

AU - Bambery, P.

AU - Sud, A.

PY - 1998

Y1 - 1998

N2 - Nitric oxide (NO) is believed to have a role in the inflammatory process. NO production was measured in 26 patients with systemic lupus erythematosus (SLE) and 20 healthy volunteers, using spectrophotometrically determined serum nitrite and citrulline as surrogate markers. Both nitrite and citrulline levels were significantly higher in patients with SLE than in controls (P < 0.001). Twelve and 10 patients, respectively, with SLE had nitrite and citrulline levels that were two standard deviations higher than the mean level of controls. These patients had a significantly higher measure of disease activity (SLE Disease Activity Index). These data show that there is increased NO production in SLE and that it may serve as a marker for disease activity.

AB - Nitric oxide (NO) is believed to have a role in the inflammatory process. NO production was measured in 26 patients with systemic lupus erythematosus (SLE) and 20 healthy volunteers, using spectrophotometrically determined serum nitrite and citrulline as surrogate markers. Both nitrite and citrulline levels were significantly higher in patients with SLE than in controls (P < 0.001). Twelve and 10 patients, respectively, with SLE had nitrite and citrulline levels that were two standard deviations higher than the mean level of controls. These patients had a significantly higher measure of disease activity (SLE Disease Activity Index). These data show that there is increased NO production in SLE and that it may serve as a marker for disease activity.

KW - Citrulline

KW - Disease activity

KW - Nitric oxide

KW - Nitrite

KW - Systemic lupus erythematosus

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Nitric oxide synthesis is increased in patients with systemic lupus erythematosus

Abstract

Keywords

ASJC Scopus subject areas

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