Nitric oxide concentrations are increased in the feto-placental circulation in intrauterine growth restriction

F. Lyall; I. A. Greer; A. Young; L. Myatt

doi:10.1016/S0143-4004(96)80009-9

Nitric oxide concentrations are increased in the feto-placental circulation in intrauterine growth restriction

F. Lyall, I. A. Greer, A. Young, L. Myatt

Research output: Contribution to journal › Article › peer-review

101 Scopus citations

Abstract

The aim of this study was to measure plasma concentrations of total nitrites, as an index of nitric oxide (NO) synthesis, in the fetal circulation of normal pregnancies and in pregnancies complicated by intrauterine growth restriction. Plasma was prepared from umbilical venous blood collected from 13 placentae from normal pregnancies and 11 pregnancies complicated by intrauterine growth restriction. Plasma NO concentrations were determined using the Greiss reaction by measuring combined oxidation products of NO, plasma nitrite (NO₂^-) and nitrate (NO₃^-) after reduction with nitrate reductase. Significantly higher NO₂^- concentrations were found in umbilical venous plasma in the group complicated by intrauterine growth restriction compared to the control group (65.6 μmol/l versus 28.7 μmol/l, P < 0.001). These results support the hypothesis that increased NO production may be a compensatory response to improve blood flow in the placenta and/or may play a role in limiting platelet adhesion and aggregation.

Original language	English (US)
Pages (from-to)	165-168
Number of pages	4
Journal	Placenta
Volume	17
Issue number	2-3
DOIs	https://doi.org/10.1016/S0143-4004(96)80009-9
State	Published - 1996
Externally published	Yes

ASJC Scopus subject areas

Reproductive Medicine
Obstetrics and Gynecology
Developmental Biology

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10.1016/S0143-4004(96)80009-9

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title = "Nitric oxide concentrations are increased in the feto-placental circulation in intrauterine growth restriction",

abstract = "The aim of this study was to measure plasma concentrations of total nitrites, as an index of nitric oxide (NO) synthesis, in the fetal circulation of normal pregnancies and in pregnancies complicated by intrauterine growth restriction. Plasma was prepared from umbilical venous blood collected from 13 placentae from normal pregnancies and 11 pregnancies complicated by intrauterine growth restriction. Plasma NO concentrations were determined using the Greiss reaction by measuring combined oxidation products of NO, plasma nitrite (NO2-) and nitrate (NO3-) after reduction with nitrate reductase. Significantly higher NO2- concentrations were found in umbilical venous plasma in the group complicated by intrauterine growth restriction compared to the control group (65.6 μmol/l versus 28.7 μmol/l, P < 0.001). These results support the hypothesis that increased NO production may be a compensatory response to improve blood flow in the placenta and/or may play a role in limiting platelet adhesion and aggregation.",

author = "F. Lyall and Greer, {I. A.} and A. Young and L. Myatt",

note = "Funding Information: This work was supported Action Research grant No. S/P 2352 and Scottish ttospitals Endowments Research Trust grant No. 1228.",

year = "1996",

doi = "10.1016/S0143-4004(96)80009-9",

language = "English (US)",

volume = "17",

pages = "165--168",

journal = "Placenta",

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T1 - Nitric oxide concentrations are increased in the feto-placental circulation in intrauterine growth restriction

AU - Lyall, F.

AU - Greer, I. A.

AU - Young, A.

AU - Myatt, L.

N1 - Funding Information: This work was supported Action Research grant No. S/P 2352 and Scottish ttospitals Endowments Research Trust grant No. 1228.

PY - 1996

Y1 - 1996

N2 - The aim of this study was to measure plasma concentrations of total nitrites, as an index of nitric oxide (NO) synthesis, in the fetal circulation of normal pregnancies and in pregnancies complicated by intrauterine growth restriction. Plasma was prepared from umbilical venous blood collected from 13 placentae from normal pregnancies and 11 pregnancies complicated by intrauterine growth restriction. Plasma NO concentrations were determined using the Greiss reaction by measuring combined oxidation products of NO, plasma nitrite (NO2-) and nitrate (NO3-) after reduction with nitrate reductase. Significantly higher NO2- concentrations were found in umbilical venous plasma in the group complicated by intrauterine growth restriction compared to the control group (65.6 μmol/l versus 28.7 μmol/l, P < 0.001). These results support the hypothesis that increased NO production may be a compensatory response to improve blood flow in the placenta and/or may play a role in limiting platelet adhesion and aggregation.

AB - The aim of this study was to measure plasma concentrations of total nitrites, as an index of nitric oxide (NO) synthesis, in the fetal circulation of normal pregnancies and in pregnancies complicated by intrauterine growth restriction. Plasma was prepared from umbilical venous blood collected from 13 placentae from normal pregnancies and 11 pregnancies complicated by intrauterine growth restriction. Plasma NO concentrations were determined using the Greiss reaction by measuring combined oxidation products of NO, plasma nitrite (NO2-) and nitrate (NO3-) after reduction with nitrate reductase. Significantly higher NO2- concentrations were found in umbilical venous plasma in the group complicated by intrauterine growth restriction compared to the control group (65.6 μmol/l versus 28.7 μmol/l, P < 0.001). These results support the hypothesis that increased NO production may be a compensatory response to improve blood flow in the placenta and/or may play a role in limiting platelet adhesion and aggregation.

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JO - Placenta

JF - Placenta

IS - 2-3

ER -

Nitric oxide concentrations are increased in the feto-placental circulation in intrauterine growth restriction

Abstract

ASJC Scopus subject areas

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