TY - JOUR
T1 - Nimodipine and chronic vasospasm in monkeys
T2 - Part 3. Cardiopulmonary effects
AU - Nosko, M.
AU - Norris, S. L.
AU - Weir, B.
AU - King, E. G.
AU - Grace, M.
PY - 1986
Y1 - 1986
N2 - A subarachnoid hemorrhage was induced in 30 cynomolgus monkeys by the placement of a 6- to 7-ml blood clot through a frontotemporal craniectomy (Day O). The monkeys underwent a 1-week-long, randomized, blind trial comparing various doses of nimodipine to placebo, sham and no treatment. The treatment groups were: nimodipine, 3 mg/kg every 8 hours (n = 6), 6 mg/kg every 8 hours (n = 6), and 12 mg/kg every 8 hours (n = 6); placebo (polyethylene glycol 400), 0.33 ml/kg every 8 hours (n =6); and no treatment (n = 6). An additional sham group underwent craniectomy without clot placement (n = 6) so that 36 animals in total were operated upon. Differences in cardiopulmonary indices between Day O and Day 7 were compared within and between groups. No significant differences were obtained in the sham and no treatment groups. The nimodipine 6- to and 12-mg/kg groups showed significant decreases in blood pressure (P < 0.04 and P < 0.015). Systemic vascular resistance was increased in the placebo and 3-mg/kg groups (P < 0.02) and decreased in the 12-mg/kg group (P < 0.015). Stroke index was increased in the 12-mg/kg group (P < 0.05). Cardiac index and stroke index correlated positively with nimodipine dosage (r = 0.99, P < 0.05). There were no pronounced changes in pulmonary artery wedge pressure, central venous pressure, alveolar-arterial oxygen pressure difference, arteriovenous oxygen content difference, and percentage of shunting.
AB - A subarachnoid hemorrhage was induced in 30 cynomolgus monkeys by the placement of a 6- to 7-ml blood clot through a frontotemporal craniectomy (Day O). The monkeys underwent a 1-week-long, randomized, blind trial comparing various doses of nimodipine to placebo, sham and no treatment. The treatment groups were: nimodipine, 3 mg/kg every 8 hours (n = 6), 6 mg/kg every 8 hours (n = 6), and 12 mg/kg every 8 hours (n = 6); placebo (polyethylene glycol 400), 0.33 ml/kg every 8 hours (n =6); and no treatment (n = 6). An additional sham group underwent craniectomy without clot placement (n = 6) so that 36 animals in total were operated upon. Differences in cardiopulmonary indices between Day O and Day 7 were compared within and between groups. No significant differences were obtained in the sham and no treatment groups. The nimodipine 6- to and 12-mg/kg groups showed significant decreases in blood pressure (P < 0.04 and P < 0.015). Systemic vascular resistance was increased in the placebo and 3-mg/kg groups (P < 0.02) and decreased in the 12-mg/kg group (P < 0.015). Stroke index was increased in the 12-mg/kg group (P < 0.05). Cardiac index and stroke index correlated positively with nimodipine dosage (r = 0.99, P < 0.05). There were no pronounced changes in pulmonary artery wedge pressure, central venous pressure, alveolar-arterial oxygen pressure difference, arteriovenous oxygen content difference, and percentage of shunting.
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U2 - 10.1227/00006123-198603000-00001
DO - 10.1227/00006123-198603000-00001
M3 - Article
C2 - 3703185
AN - SCOPUS:0022616235
SN - 0148-396X
VL - 18
SP - 261
EP - 265
JO - Neurosurgery
JF - Neurosurgery
IS - 3
ER -