Nimodipine and chronic vasospasm in monkeys: Part 3. Cardiopulmonary effects

M. Nosko, S. L. Norris, B. Weir, E. G. King, M. Grace

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A subarachnoid hemorrhage was induced in 30 cynomolgus monkeys by the placement of a 6- to 7-ml blood clot through a frontotemporal craniectomy (Day O). The monkeys underwent a 1-week-long, randomized, blind trial comparing various doses of nimodipine to placebo, sham and no treatment. The treatment groups were: nimodipine, 3 mg/kg every 8 hours (n = 6), 6 mg/kg every 8 hours (n = 6), and 12 mg/kg every 8 hours (n = 6); placebo (polyethylene glycol 400), 0.33 ml/kg every 8 hours (n =6); and no treatment (n = 6). An additional sham group underwent craniectomy without clot placement (n = 6) so that 36 animals in total were operated upon. Differences in cardiopulmonary indices between Day O and Day 7 were compared within and between groups. No significant differences were obtained in the sham and no treatment groups. The nimodipine 6- to and 12-mg/kg groups showed significant decreases in blood pressure (P <0.04 and P <0.015). Systemic vascular resistance was increased in the placebo and 3-mg/kg groups (P <0.02) and decreased in the 12-mg/kg group (P <0.015). Stroke index was increased in the 12-mg/kg group (P <0.05). Cardiac index and stroke index correlated positively with nimodipine dosage (r = 0.99, P <0.05). There were no pronounced changes in pulmonary artery wedge pressure, central venous pressure, alveolar-arterial oxygen pressure difference, arteriovenous oxygen content difference, and percentage of shunting.

Original languageEnglish (US)
Pages (from-to)261-265
Number of pages5
JournalNeurosurgery
Volume18
Issue number3
StatePublished - 1986
Externally publishedYes

Fingerprint

Nimodipine
Haplorhini
Placebos
Stroke
Oxygen
Central Venous Pressure
Pulmonary Wedge Pressure
Macaca fascicularis
Subarachnoid Hemorrhage
Vascular Resistance
Arterial Pressure
Thrombosis
Blood Pressure
Therapeutics

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

Cite this

Nosko, M., Norris, S. L., Weir, B., King, E. G., & Grace, M. (1986). Nimodipine and chronic vasospasm in monkeys: Part 3. Cardiopulmonary effects. Neurosurgery, 18(3), 261-265.

Nimodipine and chronic vasospasm in monkeys : Part 3. Cardiopulmonary effects. / Nosko, M.; Norris, S. L.; Weir, B.; King, E. G.; Grace, M.

In: Neurosurgery, Vol. 18, No. 3, 1986, p. 261-265.

Research output: Contribution to journalArticle

Nosko, M, Norris, SL, Weir, B, King, EG & Grace, M 1986, 'Nimodipine and chronic vasospasm in monkeys: Part 3. Cardiopulmonary effects', Neurosurgery, vol. 18, no. 3, pp. 261-265.
Nosko M, Norris SL, Weir B, King EG, Grace M. Nimodipine and chronic vasospasm in monkeys: Part 3. Cardiopulmonary effects. Neurosurgery. 1986;18(3):261-265.
Nosko, M. ; Norris, S. L. ; Weir, B. ; King, E. G. ; Grace, M. / Nimodipine and chronic vasospasm in monkeys : Part 3. Cardiopulmonary effects. In: Neurosurgery. 1986 ; Vol. 18, No. 3. pp. 261-265.
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