Nimodipine and chronic vasospasm in monkeys: Part 2. Pharmacological studies of vessels in spasm

C. Krueger, B. Weir, M. Nosko, D. Cook, S. Norris

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

The effect of nimodipine on the in vitro reactivity of cerebral vessels after subarachnoid hemorrhage (SAH) was studied. With the use of a primate model of chronic cerebral vasospasm, 12 female cynomolgous monkeys underwent the induction of a SAH by the direct placement of an average 6.4-ml autologous hematoma against the major anterior cerebral vessels in the right basal subarachnoid spaces (Day 0). The animals were then randomized to one of four groups and within 14 to 20 hours after clot placement were started on oral q8h therapy with nimodipine (3, 6, or 12 mg/kg) or placebo. On Day 7, the animals were killed and the right and left middle cerebral arteries (MCAs) were immediately resected and placed in oxygenated Krebs' solution. Ring preparations from the arteries were suspended in organ baths, and dose-effect curves to varying concentrations of norepinephrine, 5-hydroxytryptamine, and potassium chloride were obtained. There was a highly significant reduction in the response of the MCA on the clot side (right) relative to the nonclot side (left) to all three agonists. The clot side contractility was not influenced by nimodipine treatment at any of the four doses tested. The nonclot side arteries of the 12-mg/kg treatment group demonstrated significantly enhanced reactivity for all three agonists. Oral treatment with high dose nimodipine enhances the reactivity of normal cerebral vessels to the agonists tested, but it does not seem to affect the reactivity of arteries in chronic spasm at any of the four doses tested.

Original languageEnglish (US)
Pages (from-to)137-140
Number of pages4
JournalNeurosurgery
Volume16
Issue number2
StatePublished - 1985
Externally publishedYes

Fingerprint

Nimodipine
Spasm
Haplorhini
Pharmacology
Arteries
Middle Cerebral Artery
Subarachnoid Hemorrhage
Intracranial Vasospasm
Subarachnoid Space
Potassium Chloride
Therapeutics
Baths
Hematoma
Primates
Serotonin
Norepinephrine
Placebos

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

Cite this

Krueger, C., Weir, B., Nosko, M., Cook, D., & Norris, S. (1985). Nimodipine and chronic vasospasm in monkeys: Part 2. Pharmacological studies of vessels in spasm. Neurosurgery, 16(2), 137-140.

Nimodipine and chronic vasospasm in monkeys : Part 2. Pharmacological studies of vessels in spasm. / Krueger, C.; Weir, B.; Nosko, M.; Cook, D.; Norris, S.

In: Neurosurgery, Vol. 16, No. 2, 1985, p. 137-140.

Research output: Contribution to journalArticle

Krueger, C, Weir, B, Nosko, M, Cook, D & Norris, S 1985, 'Nimodipine and chronic vasospasm in monkeys: Part 2. Pharmacological studies of vessels in spasm', Neurosurgery, vol. 16, no. 2, pp. 137-140.
Krueger, C. ; Weir, B. ; Nosko, M. ; Cook, D. ; Norris, S. / Nimodipine and chronic vasospasm in monkeys : Part 2. Pharmacological studies of vessels in spasm. In: Neurosurgery. 1985 ; Vol. 16, No. 2. pp. 137-140.
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