Nicotinamide: suppression of lymphocyte transformation with a component identified in human transfer factor

D. R. Burger; A. A. Vandenbark; D. Daves; W. A. Anderson; R. M. Vetto; P. Finke

Nicotinamide: suppression of lymphocyte transformation with a component identified in human transfer factor

D. R. Burger, A. A. Vandenbark, D. Daves, W. A. Anderson, R. M. Vetto, P. Finke

Research output: Contribution to journal › Article › peer-review

Abstract

The component in human transfer factor (TF) (Fraction IV, from exclusion chromatography on Sephadex G 25) responsible for suppression of antigen induced lymphocyte transformation was previously identified as nicotinamide. Commercially available nicotinamide was subsequently shown to produce suppression of antigen induced responses in vitro previously observed with TF Fraction IV. Nicotinamide was found to be nontoxic at the highest concentrations employed (10 ^-2 M) and suppressive over a relatively broad range (10 ^-5 to 10 ^-2 M). The suppression appeared to be related to the magnitude of antigen or mitogen induced transformation and was apparent even when nicotinamide was added as late as 48 hr after stimulant addition.

Original language	English (US)
Pages (from-to)	797-801
Number of pages	5
Journal	Journal of Immunology
Volume	117
Issue number	3
State	Published - 1976
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy
Immunology

Cite this

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title = "Nicotinamide: suppression of lymphocyte transformation with a component identified in human transfer factor",

abstract = "The component in human transfer factor (TF) (Fraction IV, from exclusion chromatography on Sephadex G 25) responsible for suppression of antigen induced lymphocyte transformation was previously identified as nicotinamide. Commercially available nicotinamide was subsequently shown to produce suppression of antigen induced responses in vitro previously observed with TF Fraction IV. Nicotinamide was found to be nontoxic at the highest concentrations employed (10 -2 M) and suppressive over a relatively broad range (10 -5 to 10 -2 M). The suppression appeared to be related to the magnitude of antigen or mitogen induced transformation and was apparent even when nicotinamide was added as late as 48 hr after stimulant addition.",

author = "Burger, {D. R.} and Vandenbark, {A. A.} and D. Daves and Anderson, {W. A.} and Vetto, {R. M.} and P. Finke",

year = "1976",

language = "English (US)",

volume = "117",

pages = "797--801",

journal = "Journal of Immunology",

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publisher = "American Association of Immunologists",

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T1 - Nicotinamide

T2 - suppression of lymphocyte transformation with a component identified in human transfer factor

AU - Burger, D. R.

AU - Vandenbark, A. A.

AU - Daves, D.

AU - Anderson, W. A.

AU - Vetto, R. M.

AU - Finke, P.

PY - 1976

Y1 - 1976

N2 - The component in human transfer factor (TF) (Fraction IV, from exclusion chromatography on Sephadex G 25) responsible for suppression of antigen induced lymphocyte transformation was previously identified as nicotinamide. Commercially available nicotinamide was subsequently shown to produce suppression of antigen induced responses in vitro previously observed with TF Fraction IV. Nicotinamide was found to be nontoxic at the highest concentrations employed (10 -2 M) and suppressive over a relatively broad range (10 -5 to 10 -2 M). The suppression appeared to be related to the magnitude of antigen or mitogen induced transformation and was apparent even when nicotinamide was added as late as 48 hr after stimulant addition.

AB - The component in human transfer factor (TF) (Fraction IV, from exclusion chromatography on Sephadex G 25) responsible for suppression of antigen induced lymphocyte transformation was previously identified as nicotinamide. Commercially available nicotinamide was subsequently shown to produce suppression of antigen induced responses in vitro previously observed with TF Fraction IV. Nicotinamide was found to be nontoxic at the highest concentrations employed (10 -2 M) and suppressive over a relatively broad range (10 -5 to 10 -2 M). The suppression appeared to be related to the magnitude of antigen or mitogen induced transformation and was apparent even when nicotinamide was added as late as 48 hr after stimulant addition.

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C2 - 134122

AN - SCOPUS:0017163142

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ER -

Nicotinamide: suppression of lymphocyte transformation with a component identified in human transfer factor

Abstract

ASJC Scopus subject areas

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