Nicotinamide: suppression of lymphocyte transformation with a component identified in human transfer factor

D. R. Burger, Arthur Vandenbark, D. Daves, W. A. Anderson, R. M. Vetto, P. Finke

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Abstract

The component in human transfer factor (TF) (Fraction IV, from exclusion chromatography on Sephadex G 25) responsible for suppression of antigen induced lymphocyte transformation was previously identified as nicotinamide. Commercially available nicotinamide was subsequently shown to produce suppression of antigen induced responses in vitro previously observed with TF Fraction IV. Nicotinamide was found to be nontoxic at the highest concentrations employed (10 -2 M) and suppressive over a relatively broad range (10 -5 to 10 -2 M). The suppression appeared to be related to the magnitude of antigen or mitogen induced transformation and was apparent even when nicotinamide was added as late as 48 hr after stimulant addition.

Original languageEnglish (US)
Pages (from-to)797-801
Number of pages5
JournalJournal of Immunology
Volume117
Issue number3
Publication statusPublished - 1976
Externally publishedYes

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ASJC Scopus subject areas

  • Immunology

Cite this

Burger, D. R., Vandenbark, A., Daves, D., Anderson, W. A., Vetto, R. M., & Finke, P. (1976). Nicotinamide: suppression of lymphocyte transformation with a component identified in human transfer factor. Journal of Immunology, 117(3), 797-801.