Nicotinamide adenine dinucleotide-induced multimerization of the co-repressor CtBP1 relies on a switching tryptophan

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Abstract

Background: C-terminal binding protein 1 (CtBP1) assembles into a tetrameric transcriptional co-repressor but how it directs gene expression is not clear. Results: CtBP1 requires NAD(H) for transition into multimers. Its biochemical activities are separable from transcriptional repression. Conclusion: Tryptophan 318 permits CtBP1 to first dimerize and then tetramerize after the binding of NAD(H). Significance: Clarification of how CtBP1 tetramerizes will permit development of CtBP inhibitors to target oncogenesis.

Original languageEnglish (US)
Pages (from-to)27836-27848
Number of pages13
JournalJournal of Biological Chemistry
Volume288
Issue number39
DOIs
Publication statusPublished - Sep 27 2013

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ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

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