Next-generation interfaces for studying neural function

James Frank, Marc Joseph Antonini, Polina Anikeeva

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

Monitoring and modulating the diversity of signals used by neurons and glia in a closed-loop fashion is necessary to establish causative links between biochemical processes within the nervous system and observed behaviors. As developments in neural-interface hardware strive to keep pace with rapid progress in genetically encoded and synthetic reporters and modulators of neural activity, the integration of multiple functional features becomes a key requirement and a pressing challenge in the field of neural engineering. Electrical, optical and chemical approaches have been used to manipulate and record neuronal activity in vivo, with a recent focus on technologies that both integrate multiple modes of interaction with neurons into a single device and enable bidirectional communication with neural circuits with enhanced spatiotemporal precision. These technologies not only are facilitating a greater understanding of the brain, spinal cord and peripheral circuits in the context of health and disease, but also are informing the development of future closed-loop therapies for neurological, neuro-immune and neuroendocrine conditions.

Original languageEnglish (US)
JournalNature biotechnology
DOIs
StateAccepted/In press - Jan 1 2019

Fingerprint

Neurons
Biochemical Phenomena
Technology
Networks (circuits)
Neurology
Neuroglia
Nervous System
Modulators
Brain
Spinal Cord
Health
Hardware
Equipment and Supplies
Monitoring
Communication
Therapeutics

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology
  • Molecular Medicine
  • Biomedical Engineering

Cite this

Next-generation interfaces for studying neural function. / Frank, James; Antonini, Marc Joseph; Anikeeva, Polina.

In: Nature biotechnology, 01.01.2019.

Research output: Contribution to journalReview article

Frank, James ; Antonini, Marc Joseph ; Anikeeva, Polina. / Next-generation interfaces for studying neural function. In: Nature biotechnology. 2019.
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