Newborn amygdala connectivity and early emerging fear

Elina Thomas, Claudia Buss, Jerod M. Rasmussen, Sonja Entringer, Julian S.B. Ramirez, Mollie Marr, Marc D. Rudolph, John H. Gilmore, Martin Styner, Pathik D. Wadhwa, Damien Fair, Alice M. Graham

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Connectivity between the amygdala, insula (Amygdala-aI) and ventral medial prefrontal cortex (Amygdala-vmPFC) have been implicated in individual variability in fear and vulnerability to psychiatric disorders. However, it is currently unknown to what extent connectivity between these regions in the newborn period is relevant for the development of fear and other aspects of negative emotionality (NE), such as sadness. Here, we investigate newborn Am-Ins and Am-vmPFC resting state functional connectivity in relation to developmental trajectories of fear and sadness over the first two years of life using data from the Infant Behavior Questionnaire Revised (IBQ-R) and Early Childhood Behavior Questionnaire (ECBQ) (N=62). Stronger newborn amygdala connectivity predicts higher fear and sadness at 6-months-of-age and less change from 6 to 24-months-of-age. Interestingly, Am-Ins connectivity was specifically relevant for fear and not sadness, while Am-vmPFC was associated only with sadness. Associations remained consistent after considering variation in maternal sensitivity and maternal postnatal depressive symptomology. Already by the time of birth, individual differences in amygdala connectivity are relevant for the expression of fear over the first two-years-of-life. Additionally, specificity is observed, such that connections relevant for fear development are distinct from those predicting sadness trajectories.

Original languageEnglish (US)
JournalDevelopmental Cognitive Neuroscience
DOIs
StateAccepted/In press - Jan 1 2018

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Amygdala
Fear
Mothers
Infant Behavior
Prefrontal Cortex
Individuality
Psychiatry
Parturition

Keywords

  • Amygdala
  • Development
  • Fear
  • Infancy
  • Resting state fMRI
  • Sadness

ASJC Scopus subject areas

  • Cognitive Neuroscience

Cite this

Thomas, E., Buss, C., Rasmussen, J. M., Entringer, S., Ramirez, J. S. B., Marr, M., ... Graham, A. M. (Accepted/In press). Newborn amygdala connectivity and early emerging fear. Developmental Cognitive Neuroscience. https://doi.org/10.1016/j.dcn.2018.12.002

Newborn amygdala connectivity and early emerging fear. / Thomas, Elina; Buss, Claudia; Rasmussen, Jerod M.; Entringer, Sonja; Ramirez, Julian S.B.; Marr, Mollie; Rudolph, Marc D.; Gilmore, John H.; Styner, Martin; Wadhwa, Pathik D.; Fair, Damien; Graham, Alice M.

In: Developmental Cognitive Neuroscience, 01.01.2018.

Research output: Contribution to journalArticle

Thomas, E, Buss, C, Rasmussen, JM, Entringer, S, Ramirez, JSB, Marr, M, Rudolph, MD, Gilmore, JH, Styner, M, Wadhwa, PD, Fair, D & Graham, AM 2018, 'Newborn amygdala connectivity and early emerging fear', Developmental Cognitive Neuroscience. https://doi.org/10.1016/j.dcn.2018.12.002
Thomas E, Buss C, Rasmussen JM, Entringer S, Ramirez JSB, Marr M et al. Newborn amygdala connectivity and early emerging fear. Developmental Cognitive Neuroscience. 2018 Jan 1. https://doi.org/10.1016/j.dcn.2018.12.002
Thomas, Elina ; Buss, Claudia ; Rasmussen, Jerod M. ; Entringer, Sonja ; Ramirez, Julian S.B. ; Marr, Mollie ; Rudolph, Marc D. ; Gilmore, John H. ; Styner, Martin ; Wadhwa, Pathik D. ; Fair, Damien ; Graham, Alice M. / Newborn amygdala connectivity and early emerging fear. In: Developmental Cognitive Neuroscience. 2018.
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