TY - JOUR
T1 - New trends in photobiology (Invited review). UV-induced signal transduction
AU - Bender, Klaus
AU - Blattner, Christine
AU - Knebel, Axel
AU - Iordanov, Mihail
AU - Herrlich, Peter
AU - Rahmsdorf, Hans J.
N1 - Funding Information:
We would like to thank former fellows in our laboratory for working with us on the UV response. Their contribution to the work can be deduced from the reference list. Certainly, the ideas presented are a mirror of our view of the field. We apologize if we omitted, undeliberately, important points or publications or if we did not well balance out different viewpoints. We thank Ingrid Kammerer and Diane Nichol for help with the preparation of the manuscript. H.J.R. was supported by the Deutsche Forschungsgemeinschaft (Ra 247/6-1) and the Mildred-Scheel-Stifiung (W 86194 Rail and P.H. by Fonds der Chemischen Industrie.
PY - 1997/1
Y1 - 1997/1
N2 - Irradiation of cells with short wavelength ultraviolet light (UVA, B and C) induces the transcription of many genes. The program overlaps with that induced by oxidants and alkylating agents and has both protective and other functions. Genes transcribed in response to UV irradiation include genes encoding transcription factors, growth factors, proteases and viral proteins. While the transcription of trascription factor encoding genes is initiated in minutes after UV irradiation (immediate response genes) and depends exclusively on performed proteins, the transcription of protease encoding genes occurs only many hours after UV irradiation. Transcription factors controlling the activity of immediate response genes are activted by protein kinases belonging to the group of proline directed protein kinases immediately after UV irradiation. Experimental evidence suggest that these kinases are activated in UV irradiated cells through pathways which are used by growth factors. In fact, the first cellular reaction detectable in UV irradiated cells is the phosphorylation of several growth factor receptors at tyrosine residues. This phosphorylation does not depend on UV induced DNA damage, but is due to an inhibition of the activity of tyrosine phophatatases. In contrast, for late cellular reactions to UV, an obligatory role of DNA damage in transcribed regions of the genome can be demonstrated. This, UV is absorbed by several target molecules relevant for cellular signaling, and it appears that numerous signal transduction pathways are stimulated. The combined action of these pathways establishes the genetic program that determines the fate of UV irradiated cells.
AB - Irradiation of cells with short wavelength ultraviolet light (UVA, B and C) induces the transcription of many genes. The program overlaps with that induced by oxidants and alkylating agents and has both protective and other functions. Genes transcribed in response to UV irradiation include genes encoding transcription factors, growth factors, proteases and viral proteins. While the transcription of trascription factor encoding genes is initiated in minutes after UV irradiation (immediate response genes) and depends exclusively on performed proteins, the transcription of protease encoding genes occurs only many hours after UV irradiation. Transcription factors controlling the activity of immediate response genes are activted by protein kinases belonging to the group of proline directed protein kinases immediately after UV irradiation. Experimental evidence suggest that these kinases are activated in UV irradiated cells through pathways which are used by growth factors. In fact, the first cellular reaction detectable in UV irradiated cells is the phosphorylation of several growth factor receptors at tyrosine residues. This phosphorylation does not depend on UV induced DNA damage, but is due to an inhibition of the activity of tyrosine phophatatases. In contrast, for late cellular reactions to UV, an obligatory role of DNA damage in transcribed regions of the genome can be demonstrated. This, UV is absorbed by several target molecules relevant for cellular signaling, and it appears that numerous signal transduction pathways are stimulated. The combined action of these pathways establishes the genetic program that determines the fate of UV irradiated cells.
KW - Gene transcription
KW - Signal transduction
KW - Transcription factors
KW - UV irradiation
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U2 - 10.1016/S1011-1344(96)07459-3
DO - 10.1016/S1011-1344(96)07459-3
M3 - Review article
AN - SCOPUS:0031024713
SN - 1011-1344
VL - 37
SP - 1
EP - 17
JO - Journal of Photochemistry and Photobiology B: Biology
JF - Journal of Photochemistry and Photobiology B: Biology
IS - 1-2
ER -