New thoughts on female precocious puberty

Sergio Ojeda, S. Heger

    Research output: Contribution to journalArticle

    16 Citations (Scopus)

    Abstract

    Much effort has been devoted in recent years to unravel the neuroendocrine mechanisms responsible for the initiation of mammalian puberty. The concept that has emerged is that puberty results from the unfolding of a centrally originated process involving the concerted influence of neuronal systems that utilize excitatory and inhibitory amino acids as transmitters and astroglial networks that produce growth factors able to affect LHRH secretion. We discuss the idea that an isolated alteration of each of these components may result in the precocious activation of pulsatile LHRH release, and thus lead to idiopathic sexual precocity. According to this notion, such a premature activation of LHRH neuronal function would be neither associated with structural damage of the neuroendocrine brain system, nor related to a generalized activation of the neuronal-glial mechanisms underlying the onset of puberty. On the contrary, localized activation of discrete cellular subsets functionally connected to LHRH neurons would suffice to promote an increase in LHRH release of sufficient magnitude and duration to initiate the pubertal process.

    Original languageEnglish (US)
    Pages (from-to)245-256
    Number of pages12
    JournalJournal of Pediatric Endocrinology and Metabolism
    Volume14
    Issue number3
    StatePublished - 2001

    Fingerprint

    Precocious Puberty
    Gonadotropin-Releasing Hormone
    Puberty
    Neurosecretory Systems
    Excitatory Amino Acids
    Neuroglia
    Intercellular Signaling Peptides and Proteins
    Neurons
    Brain

    Keywords

    • Astroglial cells
    • Female sexual precocity
    • Gonadotropin hormone releasing hormone
    • Growth factors
    • Hypothalamus
    • Neuron-glia communication
    • Neurotransmitters

    ASJC Scopus subject areas

    • Endocrinology
    • Pediatrics, Perinatology, and Child Health

    Cite this

    New thoughts on female precocious puberty. / Ojeda, Sergio; Heger, S.

    In: Journal of Pediatric Endocrinology and Metabolism, Vol. 14, No. 3, 2001, p. 245-256.

    Research output: Contribution to journalArticle

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