New potential leads in the biology and treatment of attention deficit-hyperactivity disorder

B. J. Casey, Joel Nigg, Sarah Durston

Research output: Contribution to journalArticle

76 Citations (Scopus)

Abstract

PURPOSE OF REVIEW: This review highlights recent neuroimaging and genetic studies of attention deficit-hyperactivity disorder that may inform biologically targeted interventions and treatments. RECENT FINDINGS: The findings suggest that attention deficit-hyperactivity disorder is characterized by specific learning and cognitive deficits due to abnormalities in dopamine-rich prefrontal circuitry, of genetic or environmental origins. In addition to prefrontal cortical areas, the basal ganglia, cerebellum, and parietal cortex have been implicated in the condition. These regions are part of unique circuits that project both to and from the prefrontal cortex, thus providing a means for signaling prefrontal regions when top-down control of behavior needs to be imposed. Ineffective signaling of control systems by any one of these regions can lead to poor regulation of behavior. Likewise, intact signaling but inefficient top-down control could result in poor regulation of behavior. SUMMARY: Identification of which cognitive and neural processes are altered in attention deficit-hyperactivity disorder and acknowledgement of different casuses of the condition will lead to more individualized, biologically targeted interventions and treatments. This new direction in research and treatment has occurred as the result of a shift from diagnosis as a phenotype, to refined phenotypes of core cognitive deficits that can be more easily tied to the underlying biology.

Original languageEnglish (US)
Pages (from-to)119-124
Number of pages6
JournalCurrent Opinion in Neurology
Volume20
Issue number2
DOIs
StatePublished - Apr 2007
Externally publishedYes

Fingerprint

Attention Deficit Disorder with Hyperactivity
Phenotype
Parietal Lobe
Behavior Control
Basal Ganglia
Prefrontal Cortex
Neuroimaging
Cerebellum
Dopamine
Therapeutics
Learning
Research

Keywords

  • Attention deficit-hyperactivity disorder
  • Dopamine
  • Genetics
  • Neuroimaging
  • Prefrontal cortex

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

New potential leads in the biology and treatment of attention deficit-hyperactivity disorder. / Casey, B. J.; Nigg, Joel; Durston, Sarah.

In: Current Opinion in Neurology, Vol. 20, No. 2, 04.2007, p. 119-124.

Research output: Contribution to journalArticle

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