New observations on vitiligo and ocular disease

Michael D. Wagoner, Daniel Albert, Aaron B. Lerner, John Kirkwood, Bernadette M. Forget, James J. Nordlund

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

We examined 223 consecutive patients with vitiligo for ocular disease and 154 consecutive patients with uveitis for vitiligo to better determine the nature of the relationship between vitiligo and ocular disease. Of the 129 patients whose uveitis had an unknown cause, seven (5.4%) had cutaneous depigmentation, poliosis, or early graying of hair. The incidence is 0.5% in the general population (P<.02). None of the 25 patients whose uveitis had a known cause had vitiligo. Eleven (4.8%) of 223 patients with vitiligo had uveitis at the time of the study or had had it within the previous two years. Of 27 patients in whom vitiligo was associated with cutaneous melanoma, five (18.5%) had had uveitis within the previous two years. In three of these five, the uveitis began within one month of the appearance of cutaneous changes. Evidence of old chorioretinal scars were present in 69 of 223 patients with vitiligo (30.9%) but in only two of 148 control patients (P<.001). Sixty of 223 patients with vitiligo (26.9%) had evidence of hypopigmentation or atrophy of the retinal pigment epithelium, or both, not related to old chorioretinitis or macular degeneration but only six of 148 controls did (P<.001).

Original languageEnglish (US)
Pages (from-to)16-26
Number of pages11
JournalAmerican Journal of Ophthalmology
Volume96
Issue number1
DOIs
StatePublished - Jan 1 1983
Externally publishedYes

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Vitiligo
Eye Diseases
Uveitis
Skin
Chorioretinitis
Hypopigmentation
Time and Motion Studies
Retinal Pigment Epithelium
Macular Degeneration
Hair
Atrophy
Cicatrix
Melanoma
Incidence

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Wagoner, M. D., Albert, D., Lerner, A. B., Kirkwood, J., Forget, B. M., & Nordlund, J. J. (1983). New observations on vitiligo and ocular disease. American Journal of Ophthalmology, 96(1), 16-26. https://doi.org/10.1016/0002-9394(83)90450-6

New observations on vitiligo and ocular disease. / Wagoner, Michael D.; Albert, Daniel; Lerner, Aaron B.; Kirkwood, John; Forget, Bernadette M.; Nordlund, James J.

In: American Journal of Ophthalmology, Vol. 96, No. 1, 01.01.1983, p. 16-26.

Research output: Contribution to journalArticle

Wagoner, MD, Albert, D, Lerner, AB, Kirkwood, J, Forget, BM & Nordlund, JJ 1983, 'New observations on vitiligo and ocular disease', American Journal of Ophthalmology, vol. 96, no. 1, pp. 16-26. https://doi.org/10.1016/0002-9394(83)90450-6
Wagoner, Michael D. ; Albert, Daniel ; Lerner, Aaron B. ; Kirkwood, John ; Forget, Bernadette M. ; Nordlund, James J. / New observations on vitiligo and ocular disease. In: American Journal of Ophthalmology. 1983 ; Vol. 96, No. 1. pp. 16-26.
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