New molecular mechanisms of GH resistance

Ronald (Ron) Rosenfeld, Vivian Hwa

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Primary growth hormone (GH) resistance describes growth failure in the presence of normal, or even elevated, GH secretion. In its classic form, the phenotype is identical to that of GH deficiency, and was originally described in association with defects of the GH receptor. With increasing understanding of the GH-insulin-like growth factor (IGF) axis, it has become apparent that GH resistance can result from either primary IGF deficiency (IGFD) or IGF resistance. Primary IGFD may be due to: (i) defects of the GH receptor, (ii) defects of post-GH receptor signaling or (iii) primary defects of IGF-I synthesis. IGF resistance may result from: (i) defects of the IGF receptor, (ii) defects of post-IGF receptor signaling, (iii) defects of IGF binding proteins or (iv) defects of the epiphyseal growth plate or of regulatory proteins involved in epiphyseal growth.

Original languageEnglish (US)
JournalEuropean Journal of Endocrinology
Volume151
Issue numberSUPPL. 1
DOIs
StatePublished - Aug 2004

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Laron Syndrome
Somatomedins
Growth Hormone
Somatomedin Receptors
Growth Plate
Insulin-Like Growth Factor Binding Proteins
Growth
Insulin-Like Growth Factor I
Phenotype
Proteins

ASJC Scopus subject areas

  • Endocrinology

Cite this

New molecular mechanisms of GH resistance. / Rosenfeld, Ronald (Ron); Hwa, Vivian.

In: European Journal of Endocrinology, Vol. 151, No. SUPPL. 1, 08.2004.

Research output: Contribution to journalArticle

Rosenfeld, Ronald (Ron) ; Hwa, Vivian. / New molecular mechanisms of GH resistance. In: European Journal of Endocrinology. 2004 ; Vol. 151, No. SUPPL. 1.
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