New methods for the assessment of in vitro and in vivo stress cracking in biomedical polyurethanes

Darren J. Martin, Laura A. Poole Warren, Pathiraja A. Gunatillake, Simon McCarthy, Gordon F. Meijs, Klaus Schindhelm

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

This article describes a new test method for the assessment of the severity of environmental stress cracking of biomedical polyurethanes in a manner that minimizes the degree of subjectivity involved. The effect of applied strain and acetone pre-treatment on degradation of Pellethane 2363 80A and Pellethane 2363 55D polyurethanes under in vitro and in vivo conditions is studied. The results are presented using a magnification-weighted image rating system that allows the semi-quantitative rating of degradation based on distribution and severity of surface damage. Devices for applying controlled strain to both flat sheet and tubing samples are described. The new rating system consistently discriminated between the effects of acetone pre-treatments, strain and exposure times in both in vitro and in vivo experiments. As expected, P80A underwent considerable stress cracking compared with P55D. P80A produced similar stress crack ratings in both in vivo and in vitro experiments, however P55D performed worse under in vitro conditions compared with in vivo. This result indicated that care must be taken when interpreting in vitro results in the absence of in vivo data.

Original languageEnglish (US)
Pages (from-to)973-978
Number of pages6
JournalBiomaterials
Volume22
Issue number9
DOIs
StatePublished - May 1 2001
Externally publishedYes

Fingerprint

Polyurethanes
Acetone
Degradation
Tubing
Experiments
Cracks
In Vitro Techniques
Equipment and Supplies
pellethane 2363-55D

Keywords

  • Biostability
  • ESC
  • Pellethane
  • Polyurethane

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering

Cite this

Martin, D. J., Poole Warren, L. A., Gunatillake, P. A., McCarthy, S., Meijs, G. F., & Schindhelm, K. (2001). New methods for the assessment of in vitro and in vivo stress cracking in biomedical polyurethanes. Biomaterials, 22(9), 973-978. https://doi.org/10.1016/S0142-9612(00)00262-3

New methods for the assessment of in vitro and in vivo stress cracking in biomedical polyurethanes. / Martin, Darren J.; Poole Warren, Laura A.; Gunatillake, Pathiraja A.; McCarthy, Simon; Meijs, Gordon F.; Schindhelm, Klaus.

In: Biomaterials, Vol. 22, No. 9, 01.05.2001, p. 973-978.

Research output: Contribution to journalArticle

Martin, DJ, Poole Warren, LA, Gunatillake, PA, McCarthy, S, Meijs, GF & Schindhelm, K 2001, 'New methods for the assessment of in vitro and in vivo stress cracking in biomedical polyurethanes', Biomaterials, vol. 22, no. 9, pp. 973-978. https://doi.org/10.1016/S0142-9612(00)00262-3
Martin DJ, Poole Warren LA, Gunatillake PA, McCarthy S, Meijs GF, Schindhelm K. New methods for the assessment of in vitro and in vivo stress cracking in biomedical polyurethanes. Biomaterials. 2001 May 1;22(9):973-978. https://doi.org/10.1016/S0142-9612(00)00262-3
Martin, Darren J. ; Poole Warren, Laura A. ; Gunatillake, Pathiraja A. ; McCarthy, Simon ; Meijs, Gordon F. ; Schindhelm, Klaus. / New methods for the assessment of in vitro and in vivo stress cracking in biomedical polyurethanes. In: Biomaterials. 2001 ; Vol. 22, No. 9. pp. 973-978.
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