TY - CHAP
T1 - New Insights into the Mechanism of Lens Development Using Zebra Fish
AU - Greiling, Teri M.S.
AU - Clark, John I.
PY - 2012
Y1 - 2012
N2 - On the basis of recent advances in molecular biology, genetics, and live-embryo imaging, direct comparisons between zebra fish and human lens development are being made. The zebra fish has numerous experimental advantages for investigation of fundamental biomedical problems that are often best studied in the lens. The physical characteristics of visible light can account for the highly coordinated cell differentiation during formation of a beautifully transparent, refractile, symmetric optical element, the biological lens. The accessibility of the zebra fish lens for direct investigation during rapid development will result in new knowledge about basic functional mechanisms of epithelia-mesenchymal transitions, cell fate, cell-matrix interactions, cytoskeletal interactions, cytoplasmic crowding, membrane transport, cell adhesion, cell signaling, and metabolic specialization. The lens is well known as a model for characterization of cell and molecular aging. We review the recent advances in understanding vertebrate lens development conducted with zebra fish.
AB - On the basis of recent advances in molecular biology, genetics, and live-embryo imaging, direct comparisons between zebra fish and human lens development are being made. The zebra fish has numerous experimental advantages for investigation of fundamental biomedical problems that are often best studied in the lens. The physical characteristics of visible light can account for the highly coordinated cell differentiation during formation of a beautifully transparent, refractile, symmetric optical element, the biological lens. The accessibility of the zebra fish lens for direct investigation during rapid development will result in new knowledge about basic functional mechanisms of epithelia-mesenchymal transitions, cell fate, cell-matrix interactions, cytoskeletal interactions, cytoplasmic crowding, membrane transport, cell adhesion, cell signaling, and metabolic specialization. The lens is well known as a model for characterization of cell and molecular aging. We review the recent advances in understanding vertebrate lens development conducted with zebra fish.
KW - Embryonic development
KW - Live-embryo imaging
KW - Multiphoton
KW - Vertebrate lens
KW - Zebra fish
UR - http://www.scopus.com/inward/record.url?scp=84860466569&partnerID=8YFLogxK
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U2 - 10.1016/B978-0-12-394307-1.00001-1
DO - 10.1016/B978-0-12-394307-1.00001-1
M3 - Chapter
C2 - 22559937
AN - SCOPUS:84860466569
T3 - International Review of Cell and Molecular Biology
SP - 1
EP - 61
BT - International Review of Cell and Molecular Biology
PB - Elsevier Inc.
ER -