New Insights into the Mechanism of Lens Development Using Zebra Fish

Teri Greiling, John I. Clark

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

On the basis of recent advances in molecular biology, genetics, and live-embryo imaging, direct comparisons between zebra fish and human lens development are being made. The zebra fish has numerous experimental advantages for investigation of fundamental biomedical problems that are often best studied in the lens. The physical characteristics of visible light can account for the highly coordinated cell differentiation during formation of a beautifully transparent, refractile, symmetric optical element, the biological lens. The accessibility of the zebra fish lens for direct investigation during rapid development will result in new knowledge about basic functional mechanisms of epithelia-mesenchymal transitions, cell fate, cell-matrix interactions, cytoskeletal interactions, cytoplasmic crowding, membrane transport, cell adhesion, cell signaling, and metabolic specialization. The lens is well known as a model for characterization of cell and molecular aging. We review the recent advances in understanding vertebrate lens development conducted with zebra fish.

Original languageEnglish (US)
Pages (from-to)1-61
Number of pages61
JournalInternational Review of Cell and Molecular Biology
Volume296
DOIs
StatePublished - May 7 2012
Externally publishedYes

Fingerprint

Zebrafish
Fish
Lenses
Molecular Biology
Cell signaling
Crowding
Molecular biology
Cell Aging
Cell adhesion
Human Development
Optical devices
Cell Adhesion
Cell Communication
Vertebrates
Cell Differentiation
Embryonic Structures
Epithelium
Aging of materials
Cell Membrane
Membranes

Keywords

  • Embryonic development
  • Live-embryo imaging
  • Multiphoton
  • Vertebrate lens
  • Zebra fish

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

New Insights into the Mechanism of Lens Development Using Zebra Fish. / Greiling, Teri; Clark, John I.

In: International Review of Cell and Molecular Biology, Vol. 296, 07.05.2012, p. 1-61.

Research output: Contribution to journalArticle

@article{13df796bb8624a88aab36b3735d7ec67,
title = "New Insights into the Mechanism of Lens Development Using Zebra Fish",
abstract = "On the basis of recent advances in molecular biology, genetics, and live-embryo imaging, direct comparisons between zebra fish and human lens development are being made. The zebra fish has numerous experimental advantages for investigation of fundamental biomedical problems that are often best studied in the lens. The physical characteristics of visible light can account for the highly coordinated cell differentiation during formation of a beautifully transparent, refractile, symmetric optical element, the biological lens. The accessibility of the zebra fish lens for direct investigation during rapid development will result in new knowledge about basic functional mechanisms of epithelia-mesenchymal transitions, cell fate, cell-matrix interactions, cytoskeletal interactions, cytoplasmic crowding, membrane transport, cell adhesion, cell signaling, and metabolic specialization. The lens is well known as a model for characterization of cell and molecular aging. We review the recent advances in understanding vertebrate lens development conducted with zebra fish.",
keywords = "Embryonic development, Live-embryo imaging, Multiphoton, Vertebrate lens, Zebra fish",
author = "Teri Greiling and Clark, {John I.}",
year = "2012",
month = "5",
day = "7",
doi = "10.1016/B978-0-12-394307-1.00001-1",
language = "English (US)",
volume = "296",
pages = "1--61",
journal = "International Review of Cell and Molecular Biology",
issn = "1937-6448",
publisher = "Elsevier Inc.",

}

TY - JOUR

T1 - New Insights into the Mechanism of Lens Development Using Zebra Fish

AU - Greiling, Teri

AU - Clark, John I.

PY - 2012/5/7

Y1 - 2012/5/7

N2 - On the basis of recent advances in molecular biology, genetics, and live-embryo imaging, direct comparisons between zebra fish and human lens development are being made. The zebra fish has numerous experimental advantages for investigation of fundamental biomedical problems that are often best studied in the lens. The physical characteristics of visible light can account for the highly coordinated cell differentiation during formation of a beautifully transparent, refractile, symmetric optical element, the biological lens. The accessibility of the zebra fish lens for direct investigation during rapid development will result in new knowledge about basic functional mechanisms of epithelia-mesenchymal transitions, cell fate, cell-matrix interactions, cytoskeletal interactions, cytoplasmic crowding, membrane transport, cell adhesion, cell signaling, and metabolic specialization. The lens is well known as a model for characterization of cell and molecular aging. We review the recent advances in understanding vertebrate lens development conducted with zebra fish.

AB - On the basis of recent advances in molecular biology, genetics, and live-embryo imaging, direct comparisons between zebra fish and human lens development are being made. The zebra fish has numerous experimental advantages for investigation of fundamental biomedical problems that are often best studied in the lens. The physical characteristics of visible light can account for the highly coordinated cell differentiation during formation of a beautifully transparent, refractile, symmetric optical element, the biological lens. The accessibility of the zebra fish lens for direct investigation during rapid development will result in new knowledge about basic functional mechanisms of epithelia-mesenchymal transitions, cell fate, cell-matrix interactions, cytoskeletal interactions, cytoplasmic crowding, membrane transport, cell adhesion, cell signaling, and metabolic specialization. The lens is well known as a model for characterization of cell and molecular aging. We review the recent advances in understanding vertebrate lens development conducted with zebra fish.

KW - Embryonic development

KW - Live-embryo imaging

KW - Multiphoton

KW - Vertebrate lens

KW - Zebra fish

UR - http://www.scopus.com/inward/record.url?scp=84860466569&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84860466569&partnerID=8YFLogxK

U2 - 10.1016/B978-0-12-394307-1.00001-1

DO - 10.1016/B978-0-12-394307-1.00001-1

M3 - Article

VL - 296

SP - 1

EP - 61

JO - International Review of Cell and Molecular Biology

JF - International Review of Cell and Molecular Biology

SN - 1937-6448

ER -