New insights into the genetics of preeclampsia

T. Morgan, K. Ward

Research output: Contribution to journalArticle

47 Scopus citations

Abstract

Preeclampsia is familial. Pedigree analyses suggest that one or more common alleles may act as 'preeclampsia susceptibility genes.' The authors speculate that genes involved in blood pressure control, volume regulation, placental health, vascular disease, and vascular remodeling, underlie familial susceptibility to preeclampsia. Several candidate genes have been examined. These data suggest that a common mutation in the angiotensinogen promoter, A(-6), leads to elevated expression of this gene and pleiotropic effects, including abnormal spiral artery remodeling and failed hypervolemia of pregnancy. The factor V Leiden mutation, which predisposes women to thromboembolic disorders during pregnancy, has been implicated as another preeclampsia susceptibility gene. New insights into the genetics of preeclampsia will contribute to the understanding of this disease and should ultimately lead to improved diagnosis and treatment.

Original languageEnglish (US)
Pages (from-to)14-23
Number of pages10
JournalSeminars in Perinatology
Volume23
Issue number1
DOIs
StatePublished - Jan 1 1999

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

Fingerprint Dive into the research topics of 'New insights into the genetics of preeclampsia'. Together they form a unique fingerprint.

  • Cite this