New insights into the expanding complexity of the tumor suppressor ASPP2

Kerstin M. Kampa, Michael Bonin, Charles D. Lopez

    Research output: Contribution to journalReview articlepeer-review

    22 Scopus citations

    Abstract

    Apoptosis Stimulating Protein of p53-2, ASPP2, aka 53BP2L, (encoded by TP53BP2) is a pro-apoptotic member of a family of p53 binding proteins. ASPP2 expression is frequently suppressed in human cancers and numerous studies have consistently demonstrated that ASPP2 inhibits cell growth as well as stimulates apoptosis - at least in part through a p53-mediated pathway. Two independent mouse models have shown that ASPP2 is a haplo-insufficient tumor suppressor and underscore the importance of the role of ASPP2 in human cancer. However, mounting evidence suggests that the mechanism(s) of action for ASPP2 are complex and likely extend beyond stimulation of apoptotic programs. Data highlighting this expanding spectrum of potential ASPP2-mediated pathways is summarized along with new results from recent in vivo models suggesting new avenues for investigation.

    Original languageEnglish (US)
    Pages (from-to)2871-2876
    Number of pages6
    JournalCell Cycle
    Volume8
    Issue number18
    DOIs
    StatePublished - Sep 15 2009

    Keywords

    • ASPP2
    • Apoptosis
    • Tumor suppression
    • p53

    ASJC Scopus subject areas

    • Molecular Biology
    • Developmental Biology
    • Cell Biology

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